Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain

K. Andersen, J. Waaben, B. Husum, B. Voldby, A. Bødker, A. J. Hansen, A. Gjedde

Research output: Contribution to journalArticle

Abstract

The effect of cardiopulmonary bypass on the relationship between brain glucose consumption and regional blood flow is unknown. We measured this relationship in pigs subjected to 3 hours of pulsatile or nonpulsatile cardiopulmonary bypass at normothermia and compared the results to the relationship established in a control group of pigs. A total of 10 regions were sampled in both hemispheres of the porcine brain. In control pigs, cerebral blood flow averaged 46 ml/100 gm and the glucose consumption, 21 μmol/100 gm/min. The ratio between blood flow and glucose consumption was close to 2 ml/μmol in all regions. In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, about 2 ml/μmol. In nonpulsatile cardiopulmonary bypass regional blood flow remained normal; the average was 49 ml/100 gm/min, whereas the average glucose consumption declined to 16 μmol/100 gm. In regions with high blood flow rates, the ratio between blood flow and glucose consumption increased to about 3 ml/μmol, indicating perfusion in excess of metabolic demand. We conclude that nonpulsatile cardiopulmonary bypass at normothermia affects the metabolic flow regulation in the brain by interfering with the myogenic contractility of cerebral arterioles.

Original languageEnglish (US)
Pages (from-to)570-579
Number of pages10
JournalJournal of Thoracic and Cardiovascular Surgery
Volume90
Issue number4
StatePublished - 1985
Externally publishedYes

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Cardiopulmonary Bypass
Swine
Brain
Regional Blood Flow
Glucose
Blood Glucose
Cerebrovascular Circulation
Arterioles
Perfusion
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Andersen, K., Waaben, J., Husum, B., Voldby, B., Bødker, A., Hansen, A. J., & Gjedde, A. (1985). Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. Journal of Thoracic and Cardiovascular Surgery, 90(4), 570-579.

Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. / Andersen, K.; Waaben, J.; Husum, B.; Voldby, B.; Bødker, A.; Hansen, A. J.; Gjedde, A.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 90, No. 4, 1985, p. 570-579.

Research output: Contribution to journalArticle

Andersen, K, Waaben, J, Husum, B, Voldby, B, Bødker, A, Hansen, AJ & Gjedde, A 1985, 'Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain', Journal of Thoracic and Cardiovascular Surgery, vol. 90, no. 4, pp. 570-579.
Andersen K, Waaben J, Husum B, Voldby B, Bødker A, Hansen AJ et al. Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. Journal of Thoracic and Cardiovascular Surgery. 1985;90(4):570-579.
Andersen, K. ; Waaben, J. ; Husum, B. ; Voldby, B. ; Bødker, A. ; Hansen, A. J. ; Gjedde, A. / Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. In: Journal of Thoracic and Cardiovascular Surgery. 1985 ; Vol. 90, No. 4. pp. 570-579.
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