Nonpharmacologic Activity Interventions to Prevent Alzheimer's Disease

Research output: Chapter in Book/Report/Conference proceedingChapter


Activity-based interventions seeking to slow cognitive declines with age and delay the onset of Alzheimer's disease (AD) are on the rise and hold promise with longer-term follow-up. Physical exercise, yoga, and low-intensity physical activity embedded within one's complex social environment may impact cognitive and brain health in multiple ways that impact directly or indirectly the neuropathology and clinical symptoms of AD. Intervention efforts are increasingly targeting individuals in the community at elevated risk for AD based on poor cognitive function or the presence of known behavioral risk factors (inactivity, low education). Many of these programs are scalable through existing clinical settings and community infrastructures. At the same time, much remains to be learned about the specific activities that contribute to cognitive health and offer resilience to pathology, and the limits of their effectiveness. Questions that remain to be addressed in this developing field include dosing, incentives for adherence, and sustainability of gains postexposure. A critical objective for studies going forward will be to explore the potentially synergistic effects of multimodal interventions incorporated into daily life using real-time wearable technologies that increase measurement precision.

Original languageEnglish (US)
Title of host publicationDeveloping Therapeutics for Alzheimer's Disease
Subtitle of host publicationProgress and Challenges
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128021644
ISBN (Print)9780128021736
StatePublished - Jun 15 2016


  • Brain training
  • Cognitive activity
  • Cognitive aging
  • Exercise
  • Mild cognitive impairment
  • Multimodal
  • Neurobiology
  • Physical activity
  • Social activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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