Nonparametric sequential evaluation of diagnostic biomarkers

Aiyi Liu; Chengqing Wu; Enrique F. Schisterman

doi:10.1002/sim.3203

Nonparametric sequential evaluation of diagnostic biomarkers

Aiyi Liu, Chengqing Wu, Enrique F. Schisterman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied.

Original language	English (US)
Pages (from-to)	1667-1678
Number of pages	12
Journal	Statistics in Medicine
Volume	27
Issue number	10
DOIs	https://doi.org/10.1002/sim.3203
State	Published - May 10 2008
Externally published	Yes

Keywords

Biomarkers
Correlated U-statistics
Correlated measurements
Diagnostic tests
Interim looks and early stopping

ASJC Scopus subject areas

Epidemiology
Statistics and Probability

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10.1002/sim.3203

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AB - We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied.

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KW - Correlated measurements

KW - Diagnostic tests

KW - Interim looks and early stopping

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Nonparametric sequential evaluation of diagnostic biomarkers

Abstract

Keywords

ASJC Scopus subject areas

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