TY - JOUR
T1 - Nonneoplastic Neuroma After Radical Prostatectomy Is Not a Mimicker of Lymph Node Metastases on 68Ga–PSMA Ligand PET/CT
AU - Derlin, Thorsten
AU - Schumacher, Udo
AU - Bengel, Frank M.
PY - 2016/8/24
Y1 - 2016/8/24
N2 - ABSTRACT: Traumatic neuroma is frequently observed after surgery. PSMA expression has been demonstrated in neoplastic nerve sheath tumors, which may mimic metastases on PSMA imaging. In this case, histopathologic evaluation of a pelvic lesion with assumed intense tracer uptake on Ga-PSMA ligand PET/CT in a patient with biochemical recurrence of prostate cancer revealed an amputation neuroma. However, immunohistochemical evaluation showed absent PSMA expression, and follow-up PET confirmed persistence of the metastasis. Unlike neoplastic nerve sheath tumors, traumatic neuroma does not show PSMA expression and is not a mimicker of metastases on Ga-PSMA PET/CT.
AB - ABSTRACT: Traumatic neuroma is frequently observed after surgery. PSMA expression has been demonstrated in neoplastic nerve sheath tumors, which may mimic metastases on PSMA imaging. In this case, histopathologic evaluation of a pelvic lesion with assumed intense tracer uptake on Ga-PSMA ligand PET/CT in a patient with biochemical recurrence of prostate cancer revealed an amputation neuroma. However, immunohistochemical evaluation showed absent PSMA expression, and follow-up PET confirmed persistence of the metastasis. Unlike neoplastic nerve sheath tumors, traumatic neuroma does not show PSMA expression and is not a mimicker of metastases on Ga-PSMA PET/CT.
UR - http://www.scopus.com/inward/record.url?scp=84983247085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983247085&partnerID=8YFLogxK
U2 - 10.1097/RLU.0000000000001333
DO - 10.1097/RLU.0000000000001333
M3 - Article
C2 - 27556791
AN - SCOPUS:84983247085
SN - 0363-9762
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
ER -