Nonlinear trajectory of GFR in children before RRT

Yichen Zhong, Alvaro Munoz, George J. Schwartz, Bradley A. Warady, Susan L. Furth, Alison Gump Abraham

Research output: Contribution to journalArticle

Abstract

GFR decline in patients with CKD has been widely approximated using linear models, but this linearity assumption is not well validated.We conducted amatched case-control study in children from the Chronic Kidney Disease in Children (CKiD) cohort ages 1-16 years with mild to moderate CKD to assess whether GFR decline follows a nonlinear trajectory as CKD approaches ESRD. Children (n=125) who initiated RRT (cases) during follow-up were individually matched by CKD stage at baseline and glomerular/nonglomerular diagnosis with children (n=125) who remained RRT-free when the corresponding case initiated RRT (controls). GFR trajectories were compared using log-linear and piecewise log-linear mixed effects models adjusted for baseline characteristics. From study entry to 18 months before RRT, GFR declined 7% faster among cases compared with controls. However, GFR declined 26% faster among cases compared with controls (P

Original languageEnglish (US)
Pages (from-to)913-917
Number of pages5
JournalJournal of the American Society of Nephrology
Volume25
Issue number5
DOIs
StatePublished - May 1 2014

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Chronic Renal Insufficiency
Chronic Kidney Failure
Case-Control Studies
Linear Models

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Nonlinear trajectory of GFR in children before RRT. / Zhong, Yichen; Munoz, Alvaro; Schwartz, George J.; Warady, Bradley A.; Furth, Susan L.; Abraham, Alison Gump.

In: Journal of the American Society of Nephrology, Vol. 25, No. 5, 01.05.2014, p. 913-917.

Research output: Contribution to journalArticle

Zhong, Yichen ; Munoz, Alvaro ; Schwartz, George J. ; Warady, Bradley A. ; Furth, Susan L. ; Abraham, Alison Gump. / Nonlinear trajectory of GFR in children before RRT. In: Journal of the American Society of Nephrology. 2014 ; Vol. 25, No. 5. pp. 913-917.
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