Abstract
Brain responses to evoked pain have been extensively investigated during the past years. Medial prefrontal cortex (MPFC) has been identified as a region showing a nonlinear, quadratic response to increasing evoked deep pain. Concurrently, MPFC plays an important role as an autonomic mediator in pain perception. Therefore, we hypothesize that MPFC response to pain is directly correlated with autonomic outflow. In order to test our hypothesis, we integrated autonomic modulation with functional neuroimaging data (BOLD fMRI) obtained during evoked deep tissue pain. We selected the LF/HF ratio, estimated instantaneously through a point process approach, as a measure of sympathovagal balance. Our findings reveal that mean LF/HF values show a nonlinear, U-shaped response to increasing pain, supporting our initial hypothesis. Furthermore, we found that subjects with higher LF/HF ratios, that is, higher shift towards sympathetic outflow, also show increased activation in the ventral portion of MPFC, thus providing further evidence in support of the relevant role of this region in sympathetic modulation.
| Original language | English (US) |
|---|---|
| Title of host publication | IFMBE Proceedings |
| Pages | 1671-1674 |
| Number of pages | 4 |
| Volume | 41 |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
| Event | 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013 - Seville, Spain Duration: Sep 25 2013 → Sep 28 2013 |
Other
| Other | 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013 |
|---|---|
| Country | Spain |
| City | Seville |
| Period | 9/25/13 → 9/28/13 |
Fingerprint
Keywords
- Central autonomic network
- Deep pain
- fMRI
- Heart rate variability
- Medial prefrontal cortex
ASJC Scopus subject areas
- Biomedical Engineering
- Bioengineering
Cite this
Nonlinear relationship between perception of deep pain and medial prefrontal cortex response is related to sympathovagal balance. / Sclocco, Roberta; Loggia, M. L.; Garcia, R. G.; Edwards, R.; Kim, J.; Cerutti, S.; Bianchi, A. M.; Napadow, V.; Barbieri, R.
IFMBE Proceedings. Vol. 41 2014. p. 1671-1674.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Nonlinear relationship between perception of deep pain and medial prefrontal cortex response is related to sympathovagal balance
AU - Sclocco, Roberta
AU - Loggia, M. L.
AU - Garcia, R. G.
AU - Edwards, R.
AU - Kim, J.
AU - Cerutti, S.
AU - Bianchi, A. M.
AU - Napadow, V.
AU - Barbieri, R.
PY - 2014
Y1 - 2014
N2 - Brain responses to evoked pain have been extensively investigated during the past years. Medial prefrontal cortex (MPFC) has been identified as a region showing a nonlinear, quadratic response to increasing evoked deep pain. Concurrently, MPFC plays an important role as an autonomic mediator in pain perception. Therefore, we hypothesize that MPFC response to pain is directly correlated with autonomic outflow. In order to test our hypothesis, we integrated autonomic modulation with functional neuroimaging data (BOLD fMRI) obtained during evoked deep tissue pain. We selected the LF/HF ratio, estimated instantaneously through a point process approach, as a measure of sympathovagal balance. Our findings reveal that mean LF/HF values show a nonlinear, U-shaped response to increasing pain, supporting our initial hypothesis. Furthermore, we found that subjects with higher LF/HF ratios, that is, higher shift towards sympathetic outflow, also show increased activation in the ventral portion of MPFC, thus providing further evidence in support of the relevant role of this region in sympathetic modulation.
AB - Brain responses to evoked pain have been extensively investigated during the past years. Medial prefrontal cortex (MPFC) has been identified as a region showing a nonlinear, quadratic response to increasing evoked deep pain. Concurrently, MPFC plays an important role as an autonomic mediator in pain perception. Therefore, we hypothesize that MPFC response to pain is directly correlated with autonomic outflow. In order to test our hypothesis, we integrated autonomic modulation with functional neuroimaging data (BOLD fMRI) obtained during evoked deep tissue pain. We selected the LF/HF ratio, estimated instantaneously through a point process approach, as a measure of sympathovagal balance. Our findings reveal that mean LF/HF values show a nonlinear, U-shaped response to increasing pain, supporting our initial hypothesis. Furthermore, we found that subjects with higher LF/HF ratios, that is, higher shift towards sympathetic outflow, also show increased activation in the ventral portion of MPFC, thus providing further evidence in support of the relevant role of this region in sympathetic modulation.
KW - Central autonomic network
KW - Deep pain
KW - fMRI
KW - Heart rate variability
KW - Medial prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=84891331569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891331569&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-00846-2_412
DO - 10.1007/978-3-319-00846-2_412
M3 - Chapter
AN - SCOPUS:84891331569
SN - 9783319008455
VL - 41
SP - 1671
EP - 1674
BT - IFMBE Proceedings
ER -