Nonlinear elastic registration of brain images with tumor pathology using a biomechanical model

Stelios K. Kyriacou, Christos Davatzikos, Simion J Zinreich, R. Nick Bryan

Research output: Contribution to journalArticle

Abstract

A biomechanical model of the brain is presented, using a finite-element formulation. Emphasis is given to the modeling of the soft-tissue deformations induced by the growth of tumors and its application to the registration of anatomical atlases, with images from patients presenting such pathologies. First, an estimate of the anatomy prior to the tumor growth is obtained through a simulated biomechanical contraction of the tumor region. Then a normal-to-normal atlas registration to this estimated pre-tumor anatomy is applied. Finally, the deformation from the tumor-growth model is applied to the resultant registered atlas, producing an atlas that has been deformed to fully register to the patient images. The process of tumor growth is simulated in a nonlinear optimization framework, which is driven by anatomical features such as boundaries of brain structures. The deformation of the surrounding tissue is estimated using a nonlinear elastic model of soft tissue under the boundary conditions imposed by the skull, ventricles, and the falx and tentorium. A preliminary two-dimensional (2-D) implementation is presented in this paper, and tested on both simulated and patient data. One of the long-term goals of this work is to use anatomical brain atlases to estimate the locations of important brain structures in the brain and to use these estimates in presurgical and radiosurgical planning systems.

Original languageEnglish (US)
Pages (from-to)580-592
Number of pages13
JournalIEEE Transactions on Medical Imaging
Volume18
Issue number7
StatePublished - 1999

Fingerprint

Pathology
Atlases
Tumors
Brain
Neoplasms
Tissue
Growth
Anatomy
Nonlinear Dynamics
Skull
Boundary conditions
Planning

Keywords

  • Biomechanics
  • Brain atlas
  • Finite elements
  • Inverse methods
  • Registration
  • Surgical planning

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Nonlinear elastic registration of brain images with tumor pathology using a biomechanical model. / Kyriacou, Stelios K.; Davatzikos, Christos; Zinreich, Simion J; Nick Bryan, R.

In: IEEE Transactions on Medical Imaging, Vol. 18, No. 7, 1999, p. 580-592.

Research output: Contribution to journalArticle

Kyriacou, Stelios K. ; Davatzikos, Christos ; Zinreich, Simion J ; Nick Bryan, R. / Nonlinear elastic registration of brain images with tumor pathology using a biomechanical model. In: IEEE Transactions on Medical Imaging. 1999 ; Vol. 18, No. 7. pp. 580-592.
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