Nonlinear Associations Between Plasma Cholesterol Levels and Neuropsychological Function

Carrington R. Wendell, Alan B. Zonderman, Leslie I. Katzel, William F. Rosenberger, Victoria V. Plamadeala, Megan Hosey, Shari R. Waldstein

Research output: Contribution to journalArticle

Abstract

Objective: Although both high and low levels of total and low-density lipoprotein (LDL) cholesterol have been associated with poor neuropsychological function, little research has examined nonlinear effects. We examined quadratic relations of cholesterol to performance on a comprehensive neuropsychological battery. Method: Participants were 190 older adults (53% men, ages 54-83) free of major medical, neurologic, and psychiatric disease. Measures of fasting plasma total and high-density lipoprotein (HDL) cholesterol were assayed, and LDL cholesterol was calculated. Participants completed neuropsychological measures of attention, executive function, memory, visuospatial judgment, and manual speed and dexterity. Multiple regression analyses examined cholesterol levels as quadratic predictors of each measure of cognitive performance, with age (dichotomized as

Original languageEnglish (US)
JournalNeuropsychology
DOIs
StateAccepted/In press - Jun 9 2016

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LDL Cholesterol
Cholesterol
Executive Function
Nervous System Diseases
HDL Cholesterol
Psychiatry
Fasting
Regression Analysis
Research
Plasma

Keywords

  • Aging
  • Cognitive function
  • Lipids

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Wendell, C. R., Zonderman, A. B., Katzel, L. I., Rosenberger, W. F., Plamadeala, V. V., Hosey, M., & Waldstein, S. R. (Accepted/In press). Nonlinear Associations Between Plasma Cholesterol Levels and Neuropsychological Function. Neuropsychology. https://doi.org/10.1037/neu0000298

Nonlinear Associations Between Plasma Cholesterol Levels and Neuropsychological Function. / Wendell, Carrington R.; Zonderman, Alan B.; Katzel, Leslie I.; Rosenberger, William F.; Plamadeala, Victoria V.; Hosey, Megan; Waldstein, Shari R.

In: Neuropsychology, 09.06.2016.

Research output: Contribution to journalArticle

Wendell, CR, Zonderman, AB, Katzel, LI, Rosenberger, WF, Plamadeala, VV, Hosey, M & Waldstein, SR 2016, 'Nonlinear Associations Between Plasma Cholesterol Levels and Neuropsychological Function', Neuropsychology. https://doi.org/10.1037/neu0000298
Wendell, Carrington R. ; Zonderman, Alan B. ; Katzel, Leslie I. ; Rosenberger, William F. ; Plamadeala, Victoria V. ; Hosey, Megan ; Waldstein, Shari R. / Nonlinear Associations Between Plasma Cholesterol Levels and Neuropsychological Function. In: Neuropsychology. 2016.
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