TY - JOUR
T1 - Nonketotic Hyperglycemia Appearing as Choreoathetosis or Ballism
AU - Rector, William G.
AU - Herlong, H. Franklin
AU - Moses, Hamilton
PY - 1982
Y1 - 1982
N2 - A number of focal neurologic abnormalities may accompany severe, nonketotic hyperglycemia, but extrapyramidal movement disorders have not previously been described. We evaluated the conditions of three patients with marked hyperglycemia in whom hemichorea or ballism developed that resolved completely with normalization of the blood glucose level. Potential pathogenetic mechanisms include relative dopaminergic hypersensitivity, impaired synthesis of acetylcholine or γ-aminobutyric acid, or an undefined effect of hyperosmolarity, perhaps unmasking a previously subclinical lesion of the basal ganglia. Serum glucose level should be determined in anyone with the new onset of choreoathetosis or ballism, as hyperglycemia is a rapidly reversible cause of these conditions.
AB - A number of focal neurologic abnormalities may accompany severe, nonketotic hyperglycemia, but extrapyramidal movement disorders have not previously been described. We evaluated the conditions of three patients with marked hyperglycemia in whom hemichorea or ballism developed that resolved completely with normalization of the blood glucose level. Potential pathogenetic mechanisms include relative dopaminergic hypersensitivity, impaired synthesis of acetylcholine or γ-aminobutyric acid, or an undefined effect of hyperosmolarity, perhaps unmasking a previously subclinical lesion of the basal ganglia. Serum glucose level should be determined in anyone with the new onset of choreoathetosis or ballism, as hyperglycemia is a rapidly reversible cause of these conditions.
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U2 - 10.1001/archinte.1982.00340140156029
DO - 10.1001/archinte.1982.00340140156029
M3 - Article
C2 - 7053718
AN - SCOPUS:0020056847
SN - 0003-9926
VL - 142
SP - 154
EP - 155
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 1
ER -