Noninvasive thermal coagulation of deep subsurface tissue structures using a laser probe with integrated contact cooling.

Christopher M. Cilip, Nicholas J. Scott, Susan R. Trammell, Nathaniel M. Fried

Research output: Contribution to journalArticle


Cooling methods are used during cosmetic laser surgery to preserve a superficial layer of the skin surface. This study investigates contact cooling for sparing a deeper layer of the tissue surface during laser irradiation of subsurface tissues, with the goal of developing noninvasive laser therapy applications beyond cosmetic surgery. A laser probe was designed and tested for simultaneous laser irradiation and contact cooling of liver tissue, ex vivo. Gross and histologic examination was used to quantify thermal lesion dimensions. Liver lesions of 5.8-mm-diameter were created, while preserving the tissue surface to a depth of 1.5 mm. In vivo animal studies are planned to optimize the laser and cooling parameters for potential clinical applications.

Original languageEnglish (US)
Pages (from-to)3657-3660
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - 2008
Externally publishedYes


ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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