Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions

Raag D. Airan, Randall A. Meyer, Nicholas Ellens, Kelly R. Rhodes, Keyvan Farahani, Martin Gilbert Pomper, Shilpa D. Kadam, Jordan Green

Research output: Contribution to journalArticle

Abstract

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Toward this goal, we have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug, in this case the small molecule anesthetic propofol, upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems. These particles are potent enough that their activation can silence seizures in an acute rat seizure model. Notably, there is no evidence of brain parenchymal damage or blood-brain barrier opening with their use. Further development of these particles promises noninvasive, focal, and image-guided clinical neuromodulation along a variety of pharmacological axes.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalNano Letters
Volume17
Issue number2
DOIs
StatePublished - Feb 8 2017

Keywords

  • focused ultrasound
  • gated drug release
  • nanoparticles
  • Neuromodulation

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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