Abstract
Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.
Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours after segmental allergen challenge by using either normal-or low-dose allergen or saline. The volume of lung tissue with increased relaxation times was determined by using a threshold-based method. As a biomarker for oxygen transfer from the lungs into the blood, the oxygen transfer function (OTF) was calculated. After the third MR imaging examination, eosinophils in bronchoalveolar lavage fluid were counted. Differences between times and segments were analyzed with nonparametric Wilcoxon matched-pairs test and Spearman correlation.
Results: In lung segments treated with the standard dose of allergen, the OTF was decreased at 6 hours in asthmatic patients, compared with saline-treated segments (P = .0078). In asthmatic patients at 24 hours, the volume over threshold was significantly increased in normal allergen dose-treated segments compared with saline-treated segments (P = .004). In corresponding lung segments, the volume over threshold at 24 hours in the asthmatic group showed a positive correlation (r = 0.65, P = .0001) and the OTF at 6 hours showed an inverse correlation (r = 20.67, P = .0001) with the percentage of eosinophils in the bron-choalveolar lavage fluid.
Conclusion: OTF and volume over threshold are noninvasive MR im-aging-derived parameters to visualize and quantify the regional allergic reaction after segmental endobronchial allergen challenge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-275 |
| Number of pages | 9 |
| Journal | Radiology |
| Volume | 274 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
Cite this
Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging : A proof of concept study. / Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens.
In: Radiology, Vol. 274, No. 1, 01.01.2015, p. 267-275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging
T2 - A proof of concept study
AU - Renne, Julius
AU - Hinrichs, Jan
AU - Schönfeld, Christian
AU - Gutberlet, Marcel
AU - Winkler, Carla
AU - Faulenbach, Cornelia
AU - Jakob, Peter
AU - Schaumann, Frank
AU - Krug, Norbert
AU - Wacker, Frank
AU - Hohlfeld, Jens M.
AU - Vogel-Claussen, Jens
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours after segmental allergen challenge by using either normal-or low-dose allergen or saline. The volume of lung tissue with increased relaxation times was determined by using a threshold-based method. As a biomarker for oxygen transfer from the lungs into the blood, the oxygen transfer function (OTF) was calculated. After the third MR imaging examination, eosinophils in bronchoalveolar lavage fluid were counted. Differences between times and segments were analyzed with nonparametric Wilcoxon matched-pairs test and Spearman correlation.Results: In lung segments treated with the standard dose of allergen, the OTF was decreased at 6 hours in asthmatic patients, compared with saline-treated segments (P = .0078). In asthmatic patients at 24 hours, the volume over threshold was significantly increased in normal allergen dose-treated segments compared with saline-treated segments (P = .004). In corresponding lung segments, the volume over threshold at 24 hours in the asthmatic group showed a positive correlation (r = 0.65, P = .0001) and the OTF at 6 hours showed an inverse correlation (r = 20.67, P = .0001) with the percentage of eosinophils in the bron-choalveolar lavage fluid.Conclusion: OTF and volume over threshold are noninvasive MR im-aging-derived parameters to visualize and quantify the regional allergic reaction after segmental endobronchial allergen challenge.
AB - Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours after segmental allergen challenge by using either normal-or low-dose allergen or saline. The volume of lung tissue with increased relaxation times was determined by using a threshold-based method. As a biomarker for oxygen transfer from the lungs into the blood, the oxygen transfer function (OTF) was calculated. After the third MR imaging examination, eosinophils in bronchoalveolar lavage fluid were counted. Differences between times and segments were analyzed with nonparametric Wilcoxon matched-pairs test and Spearman correlation.Results: In lung segments treated with the standard dose of allergen, the OTF was decreased at 6 hours in asthmatic patients, compared with saline-treated segments (P = .0078). In asthmatic patients at 24 hours, the volume over threshold was significantly increased in normal allergen dose-treated segments compared with saline-treated segments (P = .004). In corresponding lung segments, the volume over threshold at 24 hours in the asthmatic group showed a positive correlation (r = 0.65, P = .0001) and the OTF at 6 hours showed an inverse correlation (r = 20.67, P = .0001) with the percentage of eosinophils in the bron-choalveolar lavage fluid.Conclusion: OTF and volume over threshold are noninvasive MR im-aging-derived parameters to visualize and quantify the regional allergic reaction after segmental endobronchial allergen challenge.
UR - http://www.scopus.com/inward/record.url?scp=84919754254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919754254&partnerID=8YFLogxK
U2 - 10.1148/radiol.14132607
DO - 10.1148/radiol.14132607
M3 - Article
C2 - 25203130
AN - SCOPUS:84919754254
VL - 274
SP - 267
EP - 275
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -