Noninvasive myocardial strain measurement by speckle tracking echocardiography: Validation against sonomicrometry and tagged magnetic resonance imaging

Brage H. Amundsen, Thomas Helle-Valle, Thor Edvardsen, Hans Torp, Jonas Crosby, Erik Lyseggen, Asbjørn Støylen, Halfdan Ihlen, Joao Lima, Otto A. Smiseth, Stig A. Slørdahl

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aim of this study was to validate speckle tracking echocardiography (STE) as a method for angle-independent measurement of regional myocardial strain, using sonomicrometry and magnetic resonance imaging (MRI) tagging as reference methods. BACKGROUND: Tissue Doppler imaging allows non-invasive measurement of myocardial strain in the left ventricle (LV), but is limited by angle dependency. METHODS: Strain measurements with STE were obtained by a custom-made program that allowed tracking of two-dimensional motion of speckle patterns in a B-mode image. In anesthetized dogs, we compared LV long- and short-axis measurements by STE to sonomicrometry during preload changes and regional myocardial ischemia. Measurements in the two orthogonal axes were obtained simultaneously in a single imaging plane. In human subjects, long-axis strain by STE and MRI tagging were compared in multiple segments of the LV. RESULTS: In the experimental study there was good correlation and agreement between STE and sonomicrometry for systolic strain in the long axis (r = 0.90, p <0.001; 95% limits of agreement -4.4% to 5.0%) and systolic shortening in the short axis (r = 0.79, p <0.001; -5.6% to 5.1%). In the clinical study, 80% of the segments could be analyzed, and correlation and agreement between STE and MRI tagging were good (r = 0.87, p <0.001; -9.1% to 8.0%). CONCLUSIONS: Speckle tracking echocardiography provides accurate and angle-independent measurements of LV dimensions and strains and has potential to become a clinical bedside tool for quantifying myocardial strain.

Original languageEnglish (US)
Pages (from-to)789-793
Number of pages5
JournalJournal of the American College of Cardiology
Volume47
Issue number4
DOIs
StatePublished - Feb 21 2006

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Echocardiography
Magnetic Resonance Imaging
Heart Ventricles
Myocardial Ischemia
Dogs

ASJC Scopus subject areas

  • Nursing(all)

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Noninvasive myocardial strain measurement by speckle tracking echocardiography : Validation against sonomicrometry and tagged magnetic resonance imaging. / Amundsen, Brage H.; Helle-Valle, Thomas; Edvardsen, Thor; Torp, Hans; Crosby, Jonas; Lyseggen, Erik; Støylen, Asbjørn; Ihlen, Halfdan; Lima, Joao; Smiseth, Otto A.; Slørdahl, Stig A.

In: Journal of the American College of Cardiology, Vol. 47, No. 4, 21.02.2006, p. 789-793.

Research output: Contribution to journalArticle

Amundsen, BH, Helle-Valle, T, Edvardsen, T, Torp, H, Crosby, J, Lyseggen, E, Støylen, A, Ihlen, H, Lima, J, Smiseth, OA & Slørdahl, SA 2006, 'Noninvasive myocardial strain measurement by speckle tracking echocardiography: Validation against sonomicrometry and tagged magnetic resonance imaging', Journal of the American College of Cardiology, vol. 47, no. 4, pp. 789-793. https://doi.org/10.1016/j.jacc.2005.10.040
Amundsen, Brage H. ; Helle-Valle, Thomas ; Edvardsen, Thor ; Torp, Hans ; Crosby, Jonas ; Lyseggen, Erik ; Støylen, Asbjørn ; Ihlen, Halfdan ; Lima, Joao ; Smiseth, Otto A. ; Slørdahl, Stig A. / Noninvasive myocardial strain measurement by speckle tracking echocardiography : Validation against sonomicrometry and tagged magnetic resonance imaging. In: Journal of the American College of Cardiology. 2006 ; Vol. 47, No. 4. pp. 789-793.
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abstract = "OBJECTIVES: The aim of this study was to validate speckle tracking echocardiography (STE) as a method for angle-independent measurement of regional myocardial strain, using sonomicrometry and magnetic resonance imaging (MRI) tagging as reference methods. BACKGROUND: Tissue Doppler imaging allows non-invasive measurement of myocardial strain in the left ventricle (LV), but is limited by angle dependency. METHODS: Strain measurements with STE were obtained by a custom-made program that allowed tracking of two-dimensional motion of speckle patterns in a B-mode image. In anesthetized dogs, we compared LV long- and short-axis measurements by STE to sonomicrometry during preload changes and regional myocardial ischemia. Measurements in the two orthogonal axes were obtained simultaneously in a single imaging plane. In human subjects, long-axis strain by STE and MRI tagging were compared in multiple segments of the LV. RESULTS: In the experimental study there was good correlation and agreement between STE and sonomicrometry for systolic strain in the long axis (r = 0.90, p <0.001; 95{\%} limits of agreement -4.4{\%} to 5.0{\%}) and systolic shortening in the short axis (r = 0.79, p <0.001; -5.6{\%} to 5.1{\%}). In the clinical study, 80{\%} of the segments could be analyzed, and correlation and agreement between STE and MRI tagging were good (r = 0.87, p <0.001; -9.1{\%} to 8.0{\%}). CONCLUSIONS: Speckle tracking echocardiography provides accurate and angle-independent measurements of LV dimensions and strains and has potential to become a clinical bedside tool for quantifying myocardial strain.",
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T1 - Noninvasive myocardial strain measurement by speckle tracking echocardiography

T2 - Validation against sonomicrometry and tagged magnetic resonance imaging

AU - Amundsen, Brage H.

AU - Helle-Valle, Thomas

AU - Edvardsen, Thor

AU - Torp, Hans

AU - Crosby, Jonas

AU - Lyseggen, Erik

AU - Støylen, Asbjørn

AU - Ihlen, Halfdan

AU - Lima, Joao

AU - Smiseth, Otto A.

AU - Slørdahl, Stig A.

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Y1 - 2006/2/21

N2 - OBJECTIVES: The aim of this study was to validate speckle tracking echocardiography (STE) as a method for angle-independent measurement of regional myocardial strain, using sonomicrometry and magnetic resonance imaging (MRI) tagging as reference methods. BACKGROUND: Tissue Doppler imaging allows non-invasive measurement of myocardial strain in the left ventricle (LV), but is limited by angle dependency. METHODS: Strain measurements with STE were obtained by a custom-made program that allowed tracking of two-dimensional motion of speckle patterns in a B-mode image. In anesthetized dogs, we compared LV long- and short-axis measurements by STE to sonomicrometry during preload changes and regional myocardial ischemia. Measurements in the two orthogonal axes were obtained simultaneously in a single imaging plane. In human subjects, long-axis strain by STE and MRI tagging were compared in multiple segments of the LV. RESULTS: In the experimental study there was good correlation and agreement between STE and sonomicrometry for systolic strain in the long axis (r = 0.90, p <0.001; 95% limits of agreement -4.4% to 5.0%) and systolic shortening in the short axis (r = 0.79, p <0.001; -5.6% to 5.1%). In the clinical study, 80% of the segments could be analyzed, and correlation and agreement between STE and MRI tagging were good (r = 0.87, p <0.001; -9.1% to 8.0%). CONCLUSIONS: Speckle tracking echocardiography provides accurate and angle-independent measurements of LV dimensions and strains and has potential to become a clinical bedside tool for quantifying myocardial strain.

AB - OBJECTIVES: The aim of this study was to validate speckle tracking echocardiography (STE) as a method for angle-independent measurement of regional myocardial strain, using sonomicrometry and magnetic resonance imaging (MRI) tagging as reference methods. BACKGROUND: Tissue Doppler imaging allows non-invasive measurement of myocardial strain in the left ventricle (LV), but is limited by angle dependency. METHODS: Strain measurements with STE were obtained by a custom-made program that allowed tracking of two-dimensional motion of speckle patterns in a B-mode image. In anesthetized dogs, we compared LV long- and short-axis measurements by STE to sonomicrometry during preload changes and regional myocardial ischemia. Measurements in the two orthogonal axes were obtained simultaneously in a single imaging plane. In human subjects, long-axis strain by STE and MRI tagging were compared in multiple segments of the LV. RESULTS: In the experimental study there was good correlation and agreement between STE and sonomicrometry for systolic strain in the long axis (r = 0.90, p <0.001; 95% limits of agreement -4.4% to 5.0%) and systolic shortening in the short axis (r = 0.79, p <0.001; -5.6% to 5.1%). In the clinical study, 80% of the segments could be analyzed, and correlation and agreement between STE and MRI tagging were good (r = 0.87, p <0.001; -9.1% to 8.0%). CONCLUSIONS: Speckle tracking echocardiography provides accurate and angle-independent measurements of LV dimensions and strains and has potential to become a clinical bedside tool for quantifying myocardial strain.

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