Noninvasive Measurement of Three-Dimensional Myocardial Deformation with Tagged Magnetic Resonance Imaging during Graded Local Ischemia

Christopher C. Moore, Elliot R. McVeigh, Elias A. Zerhouni

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to investigate the relationship between three-dimensional (3D) deformation patterns in the canine left ventricle and localized graded reductions in perfusion. Magnetic resonance (MR) tissue tagging in a clinical scanner was used to determine systolic 3D deformation throughout the left ventricle with 32-msec time resolution. Six dogs were studied at normal and reduced left anterior descending coronary artery flow levels, for a total of 14 studies. Deformation was calculated by fitting a 3D displacement field to tag displacement data from three orthogonal sets of tags and taking spatial derivatives. A novel index of 3D radial mechanical fimction, calculated from the 3D strain tensor components and the tissue incompressibility constraint, had a higher correlation (R = 0.94) with perfusion (colored microspheres) than any of the 3D Lagrangian finite strain tensor components or wall thickening. As a function of the fraction of baseline perfusion, it was well fit by a linear relationship for subnormal perfusion with a slope of 0.46 ± 0.05 and an intercept of -0.156 ± 0.026. Longitudinal strain was lost first with decreasing perfusion (48%), followed by circumferential (40%) and finally radial function (35%). The strain method detected perfusion drops as small as 20%, and early paradoxical strain transients lasting 100 msec were seen only with ischemia. 3D strain changes can be noninvasively measured throughout the left ventricle with MR tissue tagging. MR imaging-derived strain indices, unique to 3D analysis, correlate most sensitively with regional perfusion in the canine left ventricle.

Original languageEnglish (US)
Pages (from-to)207-222
Number of pages16
JournalJournal of Cardiovascular Magnetic Resonance
Volume1
Issue number3
DOIs
StatePublished - 1999

Keywords

  • 3D deformation
  • Left ventricle
  • MRI
  • Perfusion
  • Strain
  • Tissue tagging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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