Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy

Guy A. MacGowan, Edward Shapiro, Haim Azhari, Cynthia O. Siu, Paul Hees, Grover M. Hutchins, James L Weiss, Frank E. Rademakers

Research output: Contribution to journalArticle

Abstract

Background: Studies in anesthetized dogs have shown that myocardial fibers shorten ≃8%. However, in the endocardium, shortening occurs to a much greater extent at 90°to the fiber orientation ('cross-fiber shortening') than it does along the fiber direction. The purpose of this study was to estimate the extent of fiber and cross-fiber shortening in the normal human left ventricle and in patients with idiopathic dilated cardiomyopathy (IDC). Methods and Results: Ten normal subjects and nine patients with IDC were imaged with magnetic resonance tissue tagging. Finite strain analysis was used to calculate endocardial and epicardial shortening in the fiber and cross-fiber directions using anatomic fiber angles from representative autopsy specimens as references. Anatomic fiber angles were not different between normal subjects and IDC patients. Epicardial fiber strain was - 0.14±0.01 in normal subjects and -0.08±0.01 in IDC patients (P

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalCirculation
Volume96
Issue number2
StatePublished - Jul 15 1997

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Dilated Cardiomyopathy
Heart Ventricles
Endocardium
Autopsy
Magnetic Resonance Spectroscopy
Dogs
Direction compound

Keywords

  • Cardiomyopathy
  • Magnetic resonance imaging
  • Mechanics
  • Myocardial contraction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy. / MacGowan, Guy A.; Shapiro, Edward; Azhari, Haim; Siu, Cynthia O.; Hees, Paul; Hutchins, Grover M.; Weiss, James L; Rademakers, Frank E.

In: Circulation, Vol. 96, No. 2, 15.07.1997, p. 535-541.

Research output: Contribution to journalArticle

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AU - MacGowan, Guy A.

AU - Shapiro, Edward

AU - Azhari, Haim

AU - Siu, Cynthia O.

AU - Hees, Paul

AU - Hutchins, Grover M.

AU - Weiss, James L

AU - Rademakers, Frank E.

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N2 - Background: Studies in anesthetized dogs have shown that myocardial fibers shorten ≃8%. However, in the endocardium, shortening occurs to a much greater extent at 90°to the fiber orientation ('cross-fiber shortening') than it does along the fiber direction. The purpose of this study was to estimate the extent of fiber and cross-fiber shortening in the normal human left ventricle and in patients with idiopathic dilated cardiomyopathy (IDC). Methods and Results: Ten normal subjects and nine patients with IDC were imaged with magnetic resonance tissue tagging. Finite strain analysis was used to calculate endocardial and epicardial shortening in the fiber and cross-fiber directions using anatomic fiber angles from representative autopsy specimens as references. Anatomic fiber angles were not different between normal subjects and IDC patients. Epicardial fiber strain was - 0.14±0.01 in normal subjects and -0.08±0.01 in IDC patients (P

AB - Background: Studies in anesthetized dogs have shown that myocardial fibers shorten ≃8%. However, in the endocardium, shortening occurs to a much greater extent at 90°to the fiber orientation ('cross-fiber shortening') than it does along the fiber direction. The purpose of this study was to estimate the extent of fiber and cross-fiber shortening in the normal human left ventricle and in patients with idiopathic dilated cardiomyopathy (IDC). Methods and Results: Ten normal subjects and nine patients with IDC were imaged with magnetic resonance tissue tagging. Finite strain analysis was used to calculate endocardial and epicardial shortening in the fiber and cross-fiber directions using anatomic fiber angles from representative autopsy specimens as references. Anatomic fiber angles were not different between normal subjects and IDC patients. Epicardial fiber strain was - 0.14±0.01 in normal subjects and -0.08±0.01 in IDC patients (P

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