TY - JOUR
T1 - Noninvasive mapping of the normal retinal thickness at the posterior pole
AU - Asrani, Sanjay
AU - Zou, Shazhou
AU - D'Anna, Salvatore
AU - Vitale, Susan
AU - Zeimer, Ran
N1 - Funding Information:
Supported by NIH grant EY 06976 (RZ), core grant EY 1765 (Wilmer Ophthalmological Institute) from the National Eye Institute (Bethesda, MD), and a University of Illinois Scholar Award (RZ).
PY - 1999/2/1
Y1 - 1999/2/1
N2 - Objective: Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. The authors therefore developed an instrument, the Retinal Thickness Analyzer (RTA), to map the retinal thickness rapidly. The RTA was used to study the normal thickness at the posterior pole and to provide a pilot baseline. Design: Cross-sectional study. Methods: A green (540-nm) laser slit was focused on the retina via a scanning mirror placed at the conjugate plane of the pupil. The intersection between the laser slit and the retina was viewed at an angle and recorded by a video camera. Nine scans, each acquired in 200 to 400 msec, covered the central 20°of the fundus. Participants: The posterior pole was mapped in 29 normal subjects 19 to 76 years of age (mean, 48 years). Results: The thickness maps matched the posterior pole anatomy. Points with maximum thickness were located in the perifovea in a C-shaped manner extending from the disc to above and below the fovea. The local variation (standard deviation) in retinal thickness among the subjects was, on average, 15 μm. Age, gender, and race did not have a large effect (<35 μm) on the values. Conclusions: Rapid scanning thickness analysis with the RTA provides a detailed map of the retinal thickness. The relatively narrow range of thickness values in normal subjects indicates that the method may provide a sensitive detection of pathologic thickening or thinning of the retina.
AB - Objective: Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. The authors therefore developed an instrument, the Retinal Thickness Analyzer (RTA), to map the retinal thickness rapidly. The RTA was used to study the normal thickness at the posterior pole and to provide a pilot baseline. Design: Cross-sectional study. Methods: A green (540-nm) laser slit was focused on the retina via a scanning mirror placed at the conjugate plane of the pupil. The intersection between the laser slit and the retina was viewed at an angle and recorded by a video camera. Nine scans, each acquired in 200 to 400 msec, covered the central 20°of the fundus. Participants: The posterior pole was mapped in 29 normal subjects 19 to 76 years of age (mean, 48 years). Results: The thickness maps matched the posterior pole anatomy. Points with maximum thickness were located in the perifovea in a C-shaped manner extending from the disc to above and below the fovea. The local variation (standard deviation) in retinal thickness among the subjects was, on average, 15 μm. Age, gender, and race did not have a large effect (<35 μm) on the values. Conclusions: Rapid scanning thickness analysis with the RTA provides a detailed map of the retinal thickness. The relatively narrow range of thickness values in normal subjects indicates that the method may provide a sensitive detection of pathologic thickening or thinning of the retina.
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U2 - 10.1016/S0161-6420(99)90057-X
DO - 10.1016/S0161-6420(99)90057-X
M3 - Article
C2 - 9951475
AN - SCOPUS:0033504882
SN - 0161-6420
VL - 106
SP - 269
EP - 273
JO - Ophthalmology
JF - Ophthalmology
IS - 2
ER -