Noninvasive imaging of atherosclerotic plaque progression: Status of coronary computed tomography angiography

Veit Sandfort, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

The process of coronary artery disease progression is infrequently visualized. Intravascular ultrasound has been used to gain important insights but is invasive and therefore limited to high-risk patients. For low-to-moderate risk patients, noninvasive methods may be useful to quantitatively monitor plaque progression or regression and to understand and personalize atherosclerosis therapy. This review discusses the potential for coronary computed tomography angiography to evaluate the extent and subtypes of coronary plaque. Computed tomographic technology is evolving and image quality of the method approaches the level required for plaque progression monitoring. Methods to quantify plaque on computed tomography angiography are reviewed as well as a discussion of their use in clinical trials. Limitations of coronary computed tomography angiography compared with competing modalities include limited evaluation of plaque subcomponents and incomplete knowledge of the value of the method especially in patients with low-to-moderate cardiovascular risk.

Original languageEnglish (US)
Article numbere003316
JournalCirculation: Cardiovascular Imaging
Volume8
Issue number7
DOIs
StatePublished - May 1 2015

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Atherosclerotic Plaques
Disease Progression
Coronary Artery Disease
Atherosclerosis
Clinical Trials
Technology
Computed Tomography Angiography
Therapeutics

Keywords

  • Atherosclerosis
  • Atherosclerotic
  • Coronary artery disease
  • Inflammation
  • Myocardial infarction
  • Plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Noninvasive imaging of atherosclerotic plaque progression : Status of coronary computed tomography angiography. / Sandfort, Veit; Lima, Joao; Bluemke, David A.

In: Circulation: Cardiovascular Imaging, Vol. 8, No. 7, e003316, 01.05.2015.

Research output: Contribution to journalArticle

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