TY - JOUR
T1 - Noninvasive evaluation of ventricular function in cystic fibrosis
AU - Chipps, Bradley E.
AU - Alderson, Philip O.
AU - Roland, Jean Michel A.
AU - Yang, Shirley
AU - van Aswegen, Andries
AU - Martinez, Carlos R.
AU - Rosenstein, Beryl J.
N1 - Funding Information:
From the Departments of Pediatrics and Radiology, The Johns Hopkins Medical Institutions. Supported in part by United States Public Health Service Grant GM-10548, the Hospital for Comsumptives of Maryland (Eudowood), and the Cystic Fibrosis Foundation. *Reprint address': Blaloek 1139, Johns Hopkins Hospital, Baltimore, MD 21205.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1979/9
Y1 - 1979/9
N2 - The cardiac function of 21 patients with cystic fibrosis was studied using radionuclides and M-mode echocardiography. The patients (mean age 13.2 years, range 4 to 27) had a wide range of clinical and pulmonary function abnormalities (mean Shwachman-Kulczycki score 62.1). Decreased right ventricular ejection fraction was found in 13 of 18 patients (72%); an additional four patients had abnormal septal motion on ECHO. Left ventricular ejection fraction was abnormal at rest in four patients (19%); an additional four patients had borderline low LVEF. The LV pre-ejection period to ejection time ratio increased significantly (i.e., worsening LV performance) with deterioration of S-K score, chest radiograph score, and forced expiratory volume in 1 second. Three of eight patients with normal LVEF at rest had an abnormal response to supine bicycle exercise: LVEF fell in two patients and was unchanged in one. Thus evidence of LV dysfunction was observed in seven of 21 (33%) of the patients; four at rest and in three only during exercise.
AB - The cardiac function of 21 patients with cystic fibrosis was studied using radionuclides and M-mode echocardiography. The patients (mean age 13.2 years, range 4 to 27) had a wide range of clinical and pulmonary function abnormalities (mean Shwachman-Kulczycki score 62.1). Decreased right ventricular ejection fraction was found in 13 of 18 patients (72%); an additional four patients had abnormal septal motion on ECHO. Left ventricular ejection fraction was abnormal at rest in four patients (19%); an additional four patients had borderline low LVEF. The LV pre-ejection period to ejection time ratio increased significantly (i.e., worsening LV performance) with deterioration of S-K score, chest radiograph score, and forced expiratory volume in 1 second. Three of eight patients with normal LVEF at rest had an abnormal response to supine bicycle exercise: LVEF fell in two patients and was unchanged in one. Thus evidence of LV dysfunction was observed in seven of 21 (33%) of the patients; four at rest and in three only during exercise.
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U2 - 10.1016/S0022-3476(79)80510-7
DO - 10.1016/S0022-3476(79)80510-7
M3 - Article
C2 - 469660
AN - SCOPUS:0018332944
SN - 0022-3476
VL - 95
SP - 379
EP - 384
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -