Noninvasive evaluation of ventricular function in cystic fibrosis

Bradley E. Chipps, Philip O. Alderson, Jean Michel A. Roland, Shirley Yang, Andries van Aswegen, Carlos R. Martinez, Beryl J. Rosenstein

Research output: Contribution to journalArticlepeer-review

Abstract

The cardiac function of 21 patients with cystic fibrosis was studied using radionuclides and M-mode echocardiography. The patients (mean age 13.2 years, range 4 to 27) had a wide range of clinical and pulmonary function abnormalities (mean Shwachman-Kulczycki score 62.1). Decreased right ventricular ejection fraction was found in 13 of 18 patients (72%); an additional four patients had abnormal septal motion on ECHO. Left ventricular ejection fraction was abnormal at rest in four patients (19%); an additional four patients had borderline low LVEF. The LV pre-ejection period to ejection time ratio increased significantly (i.e., worsening LV performance) with deterioration of S-K score, chest radiograph score, and forced expiratory volume in 1 second. Three of eight patients with normal LVEF at rest had an abnormal response to supine bicycle exercise: LVEF fell in two patients and was unchanged in one. Thus evidence of LV dysfunction was observed in seven of 21 (33%) of the patients; four at rest and in three only during exercise.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalThe Journal of pediatrics
Volume95
Issue number3
DOIs
StatePublished - Sep 1979

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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