Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease: A proof-of-concept study

Nina Bastati, Diana Feier, Andreas Wibmer, Stefan Traussnigg, Csilla Balassy, Dietmar Tamandl, Henrik Einspieler, Friedrich Wrba, Michael Trauner, Christian Herold, Ahmed Ba-Ssalamah

Research output: Contribution to journalArticle

Abstract

Purpose: To determine whether gadoxetic acid-enhanced magnetic resonance (MR) imaging can be used to distinguish between simple steatosis and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD), defined according to the steatosis activity and fibrosis (SAF) scoring system, which is based on the semiquantitative scoring of steatosis activity and liver fibrosis. Materials and Methods: The local institutional review committee approved this study and waived written informed consent. This was a retrospective study of gadoxetic acid-enhanced 3-T MR imaging performed in 81 patients with NAFLD (45 men [56%]; mean age, 56 years; range, 25-78 years). The MR images were analyzed by using the relative enhancement (the ratio of signal intensities of the liver parenchyma before and 20 minutes after intravenous administration of gadoxetic acid). Univariate and multiple regression analyses were applied to identify variables associated with relative enhancement measurements. The ability of relative enhancement to allow differentiation between simple steatosis and NASH was assessed by using area under the receiver operating characteristic (ROC) curve analysis. Results: Relative enhancement negatively correlated with the degree of lobular inflammation (r = 20.59, P

Original languageEnglish (US)
Pages (from-to)739-747
Number of pages9
JournalRadiology
Volume271
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

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Fatty Liver
Magnetic Resonance Imaging
Advisory Committees
Informed Consent
ROC Curve
Liver Cirrhosis
Intravenous Administration
Fibrosis
Magnetic Resonance Spectroscopy
Retrospective Studies
Regression Analysis
Inflammation
gadolinium ethoxybenzyl DTPA
Non-alcoholic Fatty Liver Disease
Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease : A proof-of-concept study. / Bastati, Nina; Feier, Diana; Wibmer, Andreas; Traussnigg, Stefan; Balassy, Csilla; Tamandl, Dietmar; Einspieler, Henrik; Wrba, Friedrich; Trauner, Michael; Herold, Christian; Ba-Ssalamah, Ahmed.

In: Radiology, Vol. 271, No. 3, 2014, p. 739-747.

Research output: Contribution to journalArticle

Bastati, N, Feier, D, Wibmer, A, Traussnigg, S, Balassy, C, Tamandl, D, Einspieler, H, Wrba, F, Trauner, M, Herold, C & Ba-Ssalamah, A 2014, 'Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease: A proof-of-concept study', Radiology, vol. 271, no. 3, pp. 739-747. https://doi.org/10.1148/radiol.14131890
Bastati, Nina ; Feier, Diana ; Wibmer, Andreas ; Traussnigg, Stefan ; Balassy, Csilla ; Tamandl, Dietmar ; Einspieler, Henrik ; Wrba, Friedrich ; Trauner, Michael ; Herold, Christian ; Ba-Ssalamah, Ahmed. / Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease : A proof-of-concept study. In: Radiology. 2014 ; Vol. 271, No. 3. pp. 739-747.
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