Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy

M. Ferrari; D. A. Wilson; D. F. Hanley; J. F. Hartmann; M. C. Rogers; R. J. Traystman

Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy

M. Ferrari, D. A. Wilson, D. F. Hanley, J. F. Hartmann, M. C. Rogers, R. J. Traystman

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

An in vivo method utilizing derivative near-infrared spectroscopy was developed to noninvasively determine cerebral venous hemoglobin O₂ saturation (SV(O₂)). The method was tested on eight pentobarbital-anesthetized dogs ventilated with differing inspired O₂ mixtures to force changes in SV(O₂) over a wide range. Spectral data obtained by transilluminating the tissues surrounding the superior sagittal sinus (SS) were transformed into first derivative units for correlation with SV(O₂) data measured from the SS. Linear regression analysis was applied to data obtained from five dogs and used to build a three-wavelength algorithm for predicting brain SV(O₂). In three dogs, SV(O₂) was varied to test this equation ability to predict SV(O₂). The standard deviation of differences between measured SV(O₂) and Sv(O₂) predicted from 31 separate spectra was 3.2%. These predicted values, when regressed against the sampled SV(O₂), yielded an r value of 0.97. The results demonstrate that during hypoxic hypoxia (HH) it is possible to noninvasively quantify SV(O₂) with the use of infrared spectroscopy.

Original language	English (US)
Pages (from-to)	25/5
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	256
Issue number	5
State	Published - 1989

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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@article{72033d4d55924f90aed7c87a06c58a61,

title = "Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy",

abstract = "An in vivo method utilizing derivative near-infrared spectroscopy was developed to noninvasively determine cerebral venous hemoglobin O2 saturation (SV(O2)). The method was tested on eight pentobarbital-anesthetized dogs ventilated with differing inspired O2 mixtures to force changes in SV(O2) over a wide range. Spectral data obtained by transilluminating the tissues surrounding the superior sagittal sinus (SS) were transformed into first derivative units for correlation with SV(O2) data measured from the SS. Linear regression analysis was applied to data obtained from five dogs and used to build a three-wavelength algorithm for predicting brain SV(O2). In three dogs, SV(O2) was varied to test this equation ability to predict SV(O2). The standard deviation of differences between measured SV(O2) and Sv(O2) predicted from 31 separate spectra was 3.2%. These predicted values, when regressed against the sampled SV(O2), yielded an r value of 0.97. The results demonstrate that during hypoxic hypoxia (HH) it is possible to noninvasively quantify SV(O2) with the use of infrared spectroscopy.",

author = "M. Ferrari and Wilson, {D. A.} and Hanley, {D. F.} and Hartmann, {J. F.} and Rogers, {M. C.} and Traystman, {R. J.}",

year = "1989",

language = "English (US)",

volume = "256",

pages = "25/5",

journal = "American Journal of Physiology",

issn = "0363-6135",

publisher = "American Physiological Society",

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TY - JOUR

T1 - Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy

AU - Ferrari, M.

AU - Wilson, D. A.

AU - Hanley, D. F.

AU - Hartmann, J. F.

AU - Rogers, M. C.

AU - Traystman, R. J.

PY - 1989

Y1 - 1989

N2 - An in vivo method utilizing derivative near-infrared spectroscopy was developed to noninvasively determine cerebral venous hemoglobin O2 saturation (SV(O2)). The method was tested on eight pentobarbital-anesthetized dogs ventilated with differing inspired O2 mixtures to force changes in SV(O2) over a wide range. Spectral data obtained by transilluminating the tissues surrounding the superior sagittal sinus (SS) were transformed into first derivative units for correlation with SV(O2) data measured from the SS. Linear regression analysis was applied to data obtained from five dogs and used to build a three-wavelength algorithm for predicting brain SV(O2). In three dogs, SV(O2) was varied to test this equation ability to predict SV(O2). The standard deviation of differences between measured SV(O2) and Sv(O2) predicted from 31 separate spectra was 3.2%. These predicted values, when regressed against the sampled SV(O2), yielded an r value of 0.97. The results demonstrate that during hypoxic hypoxia (HH) it is possible to noninvasively quantify SV(O2) with the use of infrared spectroscopy.

AB - An in vivo method utilizing derivative near-infrared spectroscopy was developed to noninvasively determine cerebral venous hemoglobin O2 saturation (SV(O2)). The method was tested on eight pentobarbital-anesthetized dogs ventilated with differing inspired O2 mixtures to force changes in SV(O2) over a wide range. Spectral data obtained by transilluminating the tissues surrounding the superior sagittal sinus (SS) were transformed into first derivative units for correlation with SV(O2) data measured from the SS. Linear regression analysis was applied to data obtained from five dogs and used to build a three-wavelength algorithm for predicting brain SV(O2). In three dogs, SV(O2) was varied to test this equation ability to predict SV(O2). The standard deviation of differences between measured SV(O2) and Sv(O2) predicted from 31 separate spectra was 3.2%. These predicted values, when regressed against the sampled SV(O2), yielded an r value of 0.97. The results demonstrate that during hypoxic hypoxia (HH) it is possible to noninvasively quantify SV(O2) with the use of infrared spectroscopy.

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M3 - Article

C2 - 2719142

AN - SCOPUS:0024347804

VL - 256

SP - 25/5

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 5

ER -

Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy

Abstract

ASJC Scopus subject areas

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