Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy

Paul A Bottomley, R. J. Herfkens, L. S. Smith, S. Brazzamano, R. Blinder, L. W. Hedlund, J. L. Swain, R. W. Redington

Research output: Contribution to journalArticle

Abstract

Phosphorus (31P) NMR spectra showing the relative concentrations of phosphocreatine, ATP, and P(i) were recorded noninvasively from localized regions in the left ventricles of dog hearts in situ by using depth-resolved surface-coil spectroscopy at 1.5 T. Proton (1H) NMR surface-coil imaging was used to position 31P NMR coils and to determine the location of depth-resolved volumes immediately prior to 31P examination. Occlusion of the left anterior descending coronary artery produced regional ischemia detected as changes in the ratios of phosphocreatine, ATP, and P(i) and by changes in the pH measured from the spectra. Spectral changes were not typically observed in regions adjacent to ischemic myocardium. Reperfusion produced some recovery, and ventricular fibrillation resulted in deterioration in high-energy metabolites. The location and size of ischemic tissue was measured by single-photon-emission computed tomography (SPECT) and gamma-ray counting or by staining excised hearts. The technique should permit the long-term noninvasive monitoring of the metabolic response of the heart to pathologic processes and allow assessment of interventions.

Original languageEnglish (US)
Pages (from-to)8747-8751
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number24
StatePublished - 1985
Externally publishedYes

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Myocardial Ischemia
Magnetic Resonance Spectroscopy
Phosphocreatine
Adenosine Triphosphate
Process Assessment (Health Care)
Gamma Rays
Ventricular Fibrillation
Pathologic Processes
Single-Photon Emission-Computed Tomography
Phosphorus
Reperfusion
Heart Ventricles
Protons
Spectrum Analysis
Coronary Vessels
Myocardium
Ischemia
Dogs
Staining and Labeling
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy. / Bottomley, Paul A; Herfkens, R. J.; Smith, L. S.; Brazzamano, S.; Blinder, R.; Hedlund, L. W.; Swain, J. L.; Redington, R. W.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 24, 1985, p. 8747-8751.

Research output: Contribution to journalArticle

Bottomley, Paul A ; Herfkens, R. J. ; Smith, L. S. ; Brazzamano, S. ; Blinder, R. ; Hedlund, L. W. ; Swain, J. L. ; Redington, R. W. / Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy. In: Proceedings of the National Academy of Sciences of the United States of America. 1985 ; Vol. 82, No. 24. pp. 8747-8751.
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AU - Bottomley, Paul A

AU - Herfkens, R. J.

AU - Smith, L. S.

AU - Brazzamano, S.

AU - Blinder, R.

AU - Hedlund, L. W.

AU - Swain, J. L.

AU - Redington, R. W.

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