Abstract
In this paper, we presented a novel reference-region-based (noninvasive) bi-graphical analysis for the quantification of a reversible radiotracer binding that may be too slow to reach relative equilibrium (RE) state during positron emission tomography (PET) scans. The proposed method indirectly implements the noninvasive Logan plot, through arithmetic combination of the parameters of two other noninvasive methods and the apparent tissueto- plasma efflux rate constant for the reference region (k2). We investigated its validity and statistical properties, by performing a simulation study with various noise levels and k2 values, and also evaluated its feasibility for [18F] FP-CIT PET in human brain. The results revealed that the proposed approach provides distribution volume ratio estimation comparable to the Logan plot at low noise levels while improving underestimation caused by non-RE state differently depending on k2. Furthermore, the proposed method was able to avoid noise-induced bias of the Logan plot, and the variability of its results was less dependent on k2 than the Logan plot. Therefore, this approach, without issues related to arterial blood sampling given a pre-estimate of k2 (e.g. population-based), could be useful in parametric image generation for slow kinetic tracers staying in a non-RE state within a PET scan.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6770-6790 |
| Number of pages | 21 |
| Journal | Physics in Medicine and Biology |
| Volume | 61 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 31 2016 |
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Keywords
- distribution volume ratio
- graphical analysis
- parametric image
- positron emission tomography
- [F]FP-CIT
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Noninvasive bi-graphical analysis for the quantification of slowly reversible radioligand binding. / Seo, Seongho; Kim, Su Jin; Yoo, Hye Bin; Lee, Jee Young; Kim, Yu Kyeong; Lee, Dong Soo; Zhou, Yun; Lee, Jae Sung.
In: Physics in Medicine and Biology, Vol. 61, No. 18, 31.08.2016, p. 6770-6790.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive bi-graphical analysis for the quantification of slowly reversible radioligand binding
AU - Seo, Seongho
AU - Kim, Su Jin
AU - Yoo, Hye Bin
AU - Lee, Jee Young
AU - Kim, Yu Kyeong
AU - Lee, Dong Soo
AU - Zhou, Yun
AU - Lee, Jae Sung
PY - 2016/8/31
Y1 - 2016/8/31
N2 - In this paper, we presented a novel reference-region-based (noninvasive) bi-graphical analysis for the quantification of a reversible radiotracer binding that may be too slow to reach relative equilibrium (RE) state during positron emission tomography (PET) scans. The proposed method indirectly implements the noninvasive Logan plot, through arithmetic combination of the parameters of two other noninvasive methods and the apparent tissueto- plasma efflux rate constant for the reference region (k2). We investigated its validity and statistical properties, by performing a simulation study with various noise levels and k2 values, and also evaluated its feasibility for [18F] FP-CIT PET in human brain. The results revealed that the proposed approach provides distribution volume ratio estimation comparable to the Logan plot at low noise levels while improving underestimation caused by non-RE state differently depending on k2. Furthermore, the proposed method was able to avoid noise-induced bias of the Logan plot, and the variability of its results was less dependent on k2 than the Logan plot. Therefore, this approach, without issues related to arterial blood sampling given a pre-estimate of k2 (e.g. population-based), could be useful in parametric image generation for slow kinetic tracers staying in a non-RE state within a PET scan.
AB - In this paper, we presented a novel reference-region-based (noninvasive) bi-graphical analysis for the quantification of a reversible radiotracer binding that may be too slow to reach relative equilibrium (RE) state during positron emission tomography (PET) scans. The proposed method indirectly implements the noninvasive Logan plot, through arithmetic combination of the parameters of two other noninvasive methods and the apparent tissueto- plasma efflux rate constant for the reference region (k2). We investigated its validity and statistical properties, by performing a simulation study with various noise levels and k2 values, and also evaluated its feasibility for [18F] FP-CIT PET in human brain. The results revealed that the proposed approach provides distribution volume ratio estimation comparable to the Logan plot at low noise levels while improving underestimation caused by non-RE state differently depending on k2. Furthermore, the proposed method was able to avoid noise-induced bias of the Logan plot, and the variability of its results was less dependent on k2 than the Logan plot. Therefore, this approach, without issues related to arterial blood sampling given a pre-estimate of k2 (e.g. population-based), could be useful in parametric image generation for slow kinetic tracers staying in a non-RE state within a PET scan.
KW - distribution volume ratio
KW - graphical analysis
KW - parametric image
KW - positron emission tomography
KW - [F]FP-CIT
UR - http://www.scopus.com/inward/record.url?scp=84991316079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991316079&partnerID=8YFLogxK
U2 - 10.1088/0031-9155/61/18/6770
DO - 10.1088/0031-9155/61/18/6770
M3 - Article
VL - 61
SP - 6770
EP - 6790
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 18
ER -