Noninvasive assessment of myocardial stunning from short-term coronary occlusion using tagged magnetic resonance imaging

Dara Kraitchman, Hanns B. Hillenbrand, Izlem Oznur, Joao Lima, Elliot R. McVeigh, Elias Zerhouni, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Brief myocardial ischemia of less than 20 min duration, followed by reperfusion, is known to cause transient contractile dysfunction, often termed myocardial stunning. Tagged magnetic resonance imaging offers a noninvasive method that can be used to quantify this regional mechanical dysfunction in stunned myocardium. To this end, a closed-chest canine model of myocardial stunning was created by short-term (~20-min) coronary occlusion, via inflation of an angioplasty balloon placed fluoroscopically in the left anterior descending (LAD) coronary, followed by reperfusion. Changes in myocardial strain before occlusion, during occlusion, and at 15 and 30 min after reperfusion were determined using repeated-measures analysis of variance. After instrumentation but before coronary occlusion, global reductions in myocardial strain were observed relative to animals that did not undergo coronary catheterization procedures. Declines of 46% and 49% in regional myocardial blood flow in the LAD and left circumflex bed, respectively, from preinstrumentation levels occurred due to coronary angiography and placement of a deflated angioplasty balloon in the LAD for 1 hr. During LAD occlusion, maximum myocardial shortening was significantly reduced in the anterior and anteroseptal regions of the left ventricular apex (i.e., ischemic region) but returned to baseline values by 30 min after reperfusion. No augmentation of myocardial function was observed in the nonischemic regions during occlusion or reperfusion. Thus, this noninvasive technique to evaluate myocardial ischemia demonstrated a graded response in myocardial function to ischemia and persistent regional dysfunction or 'myocardial stunning' after short-term coronary occlusion.

Original languageEnglish (US)
Pages (from-to)123-136
Number of pages14
JournalJournal of Cardiovascular Magnetic Resonance
Volume2
Issue number2
StatePublished - 2000

Fingerprint

Myocardial Stunning
Coronary Occlusion
Reperfusion
Magnetic Resonance Imaging
Balloon Angioplasty
Myocardial Ischemia
Myocardial Reperfusion
Regional Blood Flow
Economic Inflation
Coronary Angiography
Catheterization
Canidae
Analysis of Variance
Thorax
Ischemia

Keywords

  • MR tagging
  • Myocardial function
  • Myocardial ischemia
  • Myocardial stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this

Noninvasive assessment of myocardial stunning from short-term coronary occlusion using tagged magnetic resonance imaging. / Kraitchman, Dara; Hillenbrand, Hanns B.; Oznur, Izlem; Lima, Joao; McVeigh, Elliot R.; Zerhouni, Elias; Bluemke, David A.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 2, No. 2, 2000, p. 123-136.

Research output: Contribution to journalArticle

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