Noninvasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography

Michael J. Cobb, Yuchuan Chen, Robert A. Underwood, Marcia L. Usui, John Olerud, Xingde Li

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Ultrahigh-resolution optical coherence tomography (OCT) was used for noninvasive in vivo evaluation of the wound healing process. Cutaneous wounds were induced by 2.5-mm diameter fullthickness punch biopsies on the dorsal surface of seven mice. OCT imaging was performed to assess the structural characteristics associated with the healing process. The OCT results were compared to corresponding histology. Two automated quantitative analysis routines were implemented to identify the dermal-epidermal junction and segment the OCT images. Hallmarks of cutaneous wound healing such as wound size, epidermal migration, dermal-epidermal junction formation, and differences in wound composition were readily identified on the OCT images. Blister formation was also observed. Preliminary findings suggest OCT is a viable tool to noninvasively monitor wound healing in vivo.

Original languageEnglish (US)
Article number064002
JournalJournal of biomedical optics
Issue number6
StatePublished - Nov 2006
Externally publishedYes


  • Image segmentation and imaging
  • Optical coherence tomography
  • Wound healing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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