Noninvasive assessment of cancer response to therapy

Zhaozhong Han, Allie Fu, Hailun Wang, Roberto Diaz, Ling Geng, Halina Onishko, Dennis E. Hallahan

Research output: Contribution to journalArticle

Abstract

Rapid assessment of cancer response to a therapeutic regimen can determine efficacy early in the course of treatment. Although biopsies of cancer can be used to rapidly assess pharmacodynamic response, certain disease sites are less accessible to repeated biopsies. Here, we simultaneously assess response in all sites of disease within days of starting therapy by use of peptide ligands selected for their ability to discern responding from nonresponding cancers. When conjugated to near-infrared imaging agents, the HVGGSSV peptide differentiates between these two types of cancer. Rapid, noninvasive assessment of the pharmacodynamic response within cancer promises to accelerate drug development and minimize the duration of treatment with ineffective regimens in cancer patients.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalNature medicine
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Han, Z., Fu, A., Wang, H., Diaz, R., Geng, L., Onishko, H., & Hallahan, D. E. (2008). Noninvasive assessment of cancer response to therapy. Nature medicine, 14(3), 343-349. https://doi.org/10.1038/nm1691