Noninteraction of temazepam and cimetidine

David J. Greenblatt, Darrell R. Abernethy, Marcia Divoll, Ann Locniskar, Jerold S. Harmatz, Richard I. Shader

Research output: Contribution to journalArticlepeer-review

Abstract

The possible kinetic interaction of the hypnotic temazepam and the H2‐receptor antagonist cimetidine was evaluated. Nine healthy male and female volunteers received a 30‐mg oral dose of temazepam on two occasions in random sequence, separated by at least 1 week. On one occasion, temazepam was given in the otherwise drug‐free state; on the other, temazepam was given with concurrent administration of cimetidine, 300 mg every 6 h. Mean pharmacokinetic parameters for temazepam in control versus cimetidine trials were: peak plasma concentration, 560 versus 498 ng/mL; time of peak concentration, 2.0 versus 2.1 h after the dose; volume of distribution, 1.30 versus 1.39 L/kg; elimination half‐life, 9.9 versus 11.4 h; total clearance, 1.59 versus 1.60 mL/min/kg; free fraction of temazepam in plasma, 4.1 versus 3.8% unbound. Cimetidine has been shown to reduce the metabolic clearance of the benzodiazepines that are biotransformed by oxidative mechanisms. Temazepam, transformed by conjugation, appears unaffected by the coadministration of cimetidine.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume73
Issue number3
DOIs
StatePublished - Mar 1984

Keywords

  • Cimetidine—noninteraction with temazepam, pharmacokinetics
  • Pharmacokinetics—noninteraction of temazepam and cimetine
  • Temazepam—noninteraction with cimetidine, pharmacokinetics

ASJC Scopus subject areas

  • Pharmaceutical Science

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