Abstract
Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the “dark matter in life,” functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 191-215 |
| Number of pages | 25 |
| Volume | 927 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 927 |
| ISSN (Print) | 00652598 |
| ISSN (Electronic) | 22148019 |
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Keywords
- Amino acid
- Cancer metabolism
- Glucose
- Lipid
- Long noncoding RNA
- MicroRNA
- Noncoding RNA
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Noncoding RNAs in regulation of cancer metabolic reprogramming. / Yang, Dongdong; Sun, Linchong; Li, Zhaoyong; Gao, Ping.
Advances in Experimental Medicine and Biology. Vol. 927 Springer New York LLC, 2016. p. 191-215 (Advances in Experimental Medicine and Biology; Vol. 927).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Noncoding RNAs in regulation of cancer metabolic reprogramming
AU - Yang, Dongdong
AU - Sun, Linchong
AU - Li, Zhaoyong
AU - Gao, Ping
PY - 2016
Y1 - 2016
N2 - Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the “dark matter in life,” functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.
AB - Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the “dark matter in life,” functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.
KW - Amino acid
KW - Cancer metabolism
KW - Glucose
KW - Lipid
KW - Long noncoding RNA
KW - MicroRNA
KW - Noncoding RNA
UR - http://www.scopus.com/inward/record.url?scp=84982746795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982746795&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-1498-7_7
DO - 10.1007/978-981-10-1498-7_7
M3 - Chapter
AN - SCOPUS:84982746795
VL - 927
T3 - Advances in Experimental Medicine and Biology
SP - 191
EP - 215
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -