Noncoding RNAs in regulation of cancer metabolic reprogramming

Dongdong Yang, Linchong Sun, Zhaoyong Li, Ping Gao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the “dark matter in life,” functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages191-215
Number of pages25
Volume927
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume927
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Amino acid
  • Cancer metabolism
  • Glucose
  • Lipid
  • Long noncoding RNA
  • MicroRNA
  • Noncoding RNA

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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