@article{53c8d4d282584b3e970b049152def71c,
title = "Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3",
abstract = "How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.",
author = "Dongwon Kim and Ruosi Chen and Mary Sheu and Noori Kim and Sooah Kim and Nasif Islam and Wier, {Eric M.} and Gaofeng Wang and Ang Li and Angela Park and Wooyang Son and Benjamin Evans and Victoria Yu and Prizmic, {Vicky P.} and Eugene Oh and Zixiao Wang and Jianshi Yu and Weiliang Huang and Archer, {Nathan K.} and Zhiqi Hu and Nashay Clemetson and Nelson, {Amanda M.} and Anna Chien and Okoye, {Ginette A.} and Miller, {Lloyd S.} and Gabriel Ghiaur and Sewon Kang and Jones, {Jace W.} and Kane, {Maureen A.} and Garza, {Luis A.}",
note = "Funding Information: The authors thank the Cutaneous Translational Research Program (CTReP) at the Department of Dermatology for organizing human subjects and preparing tissue samples. The authors also thank Conover Talbot Jr. (JHMI Deep Sequencing and Microarray Core) for assistance with microarray analysis. Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health, under R01AR064297 and AR068280 to LAG. This work was also supported by the Department of Defense, Armed Forces Institute of Regenerative Medicine, Extremities Regeneration (AFIRM2-ER11), CDMRMP W81XWH-16-C-0167 and Northrop Grumman Electronic Systems as well as the Thomas Provost, MD Young Faculty Development Fund of Johns Hopkins Dermatology to LAG. Dongwon Kim was supported by post-doctoral fellowship from Maryland Stem Cell Research Grant (2017-MSCRFF-3905). Additional support was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, under R01HD077260 to MAK and by the University of Maryland School of Pharmacy Mass Spectrometry Center (SOP1841-IQB2014). Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-10811-y",
language = "English (US)",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}