Noncalcifed coronary plaque volumes in healthy people with a family history of early onset coronary artery disease

Brian G Kral, Lewis Becker, Dhananjay Vaidya, Lisa Yanek, Rehan Qayyum, Stefan Zimmerman, Damini Dey, Daniel S. Berman, Taryn F. Moy, Elliot K Fishman, Diane M Becker

Research output: Contribution to journalArticle

Abstract

Background-Although age and sex distributions of calcifed coronary plaque have been well described in the general population, noncalcifed plaque (NCP) distributions remain unknown. This is important because NCP is a putative precursor for clinical coronary artery disease and could serve as a sentinel for aggressive primary prevention, especially in high-risk populations. We examined the distributions of NCP and calcifed coronary plaque in healthy 30- to 74-year-old individuals from families with early onset coronary artery disease. Methods and Results-Participants in the GeneSTAR family study (N=805), mean age 51.1±10.8 years, 56% women, were screened for coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes (mm3) were quantifed using a validated automated method. The prevalence of coronary plaque was 57.8% in men and 35.8% in women (P70% and >80%, respectively). Higher Framingham risk was associated with the number of affected vessels (P

Original languageEnglish (US)
Pages (from-to)446-453
Number of pages8
JournalCirculation: Cardiovascular Imaging
Volume7
Issue number3
DOIs
StatePublished - 2014

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Coronary Artery Disease
Sex Distribution
Age Distribution
Primary Prevention
Population
Angiography
cyhalothrin

Keywords

  • Asymptomatic diseases
  • Atherosclerosis
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

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title = "Noncalcifed coronary plaque volumes in healthy people with a family history of early onset coronary artery disease",
abstract = "Background-Although age and sex distributions of calcifed coronary plaque have been well described in the general population, noncalcifed plaque (NCP) distributions remain unknown. This is important because NCP is a putative precursor for clinical coronary artery disease and could serve as a sentinel for aggressive primary prevention, especially in high-risk populations. We examined the distributions of NCP and calcifed coronary plaque in healthy 30- to 74-year-old individuals from families with early onset coronary artery disease. Methods and Results-Participants in the GeneSTAR family study (N=805), mean age 51.1±10.8 years, 56{\%} women, were screened for coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes (mm3) were quantifed using a validated automated method. The prevalence of coronary plaque was 57.8{\%} in men and 35.8{\%} in women (P70{\%} and >80{\%}, respectively). Higher Framingham risk was associated with the number of affected vessels (P",
keywords = "Asymptomatic diseases, Atherosclerosis, Multidetector computed tomography",
author = "Kral, {Brian G} and Lewis Becker and Dhananjay Vaidya and Lisa Yanek and Rehan Qayyum and Stefan Zimmerman and Damini Dey and Berman, {Daniel S.} and Moy, {Taryn F.} and Fishman, {Elliot K} and Becker, {Diane M}",
year = "2014",
doi = "10.1161/CIRCIMAGING.113.000980",
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AU - Kral, Brian G

AU - Becker, Lewis

AU - Vaidya, Dhananjay

AU - Yanek, Lisa

AU - Qayyum, Rehan

AU - Zimmerman, Stefan

AU - Dey, Damini

AU - Berman, Daniel S.

AU - Moy, Taryn F.

AU - Fishman, Elliot K

AU - Becker, Diane M

PY - 2014

Y1 - 2014

N2 - Background-Although age and sex distributions of calcifed coronary plaque have been well described in the general population, noncalcifed plaque (NCP) distributions remain unknown. This is important because NCP is a putative precursor for clinical coronary artery disease and could serve as a sentinel for aggressive primary prevention, especially in high-risk populations. We examined the distributions of NCP and calcifed coronary plaque in healthy 30- to 74-year-old individuals from families with early onset coronary artery disease. Methods and Results-Participants in the GeneSTAR family study (N=805), mean age 51.1±10.8 years, 56% women, were screened for coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes (mm3) were quantifed using a validated automated method. The prevalence of coronary plaque was 57.8% in men and 35.8% in women (P70% and >80%, respectively). Higher Framingham risk was associated with the number of affected vessels (P

AB - Background-Although age and sex distributions of calcifed coronary plaque have been well described in the general population, noncalcifed plaque (NCP) distributions remain unknown. This is important because NCP is a putative precursor for clinical coronary artery disease and could serve as a sentinel for aggressive primary prevention, especially in high-risk populations. We examined the distributions of NCP and calcifed coronary plaque in healthy 30- to 74-year-old individuals from families with early onset coronary artery disease. Methods and Results-Participants in the GeneSTAR family study (N=805), mean age 51.1±10.8 years, 56% women, were screened for coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes (mm3) were quantifed using a validated automated method. The prevalence of coronary plaque was 57.8% in men and 35.8% in women (P70% and >80%, respectively). Higher Framingham risk was associated with the number of affected vessels (P

KW - Asymptomatic diseases

KW - Atherosclerosis

KW - Multidetector computed tomography

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