TY - JOUR
T1 - Nonbacterial thrombotic endocarditis in cancer patients
T2 - Pathogenesis, diagnosis, and treatment
AU - El-Shami, Khaled
AU - Griffiths, Elizabeth
AU - Streiff, Michael
PY - 2007
Y1 - 2007
N2 - Thrombophilia is a well-described consequence of cancer and its treatment. The pathogenesis of this phenomenon is complex and multifactorial. Nonbacterial thrombotic endocarditis (NBTE) is a serious and potentially underdiagnosed manifestation of this prothrombotic state that can cause substantial morbidity in affected patients, most notably recurrent or multiple ischemic cerebrovascular strokes. Diagnosis of NBTE requires a high degree of clinical suspicion as well as the judicious use of two-dimensional echocardiography to document the presence of valvular thrombi. In the absence of contraindications to therapy, treatment consists of systemic anticoagulation, which may ameliorate symptoms and prevent further thromboembolic episodes, as well as control of the underlying malignancy whenever possible.
AB - Thrombophilia is a well-described consequence of cancer and its treatment. The pathogenesis of this phenomenon is complex and multifactorial. Nonbacterial thrombotic endocarditis (NBTE) is a serious and potentially underdiagnosed manifestation of this prothrombotic state that can cause substantial morbidity in affected patients, most notably recurrent or multiple ischemic cerebrovascular strokes. Diagnosis of NBTE requires a high degree of clinical suspicion as well as the judicious use of two-dimensional echocardiography to document the presence of valvular thrombi. In the absence of contraindications to therapy, treatment consists of systemic anticoagulation, which may ameliorate symptoms and prevent further thromboembolic episodes, as well as control of the underlying malignancy whenever possible.
KW - Anticoagulation
KW - Cancer
KW - Nonbacterial thrombotic endocarditis
UR - http://www.scopus.com/inward/record.url?scp=34547582503&partnerID=8YFLogxK
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U2 - 10.1634/theoncologist.12-5-518
DO - 10.1634/theoncologist.12-5-518
M3 - Review article
C2 - 17522239
AN - SCOPUS:34547582503
SN - 1083-7159
VL - 12
SP - 518
EP - 523
JO - Oncologist
JF - Oncologist
IS - 5
ER -