Nonadministration of pharmacologic venous thromboembolism prophylaxis is less common in hospitalized patients with COVID-19

Mujan Varasteh Kia, Brandyn D. Lau, Oluwafemi P. Owodunni, Peggy S. Kraus, Christine G. Holzmueller, Deborah B. Hobson, Dauryne L. Shaffer, Michael B. Streiff, Elliott R. Haut

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The incidence of venous thromboembolism (VTE) in patients hospitalized with COVID-19 is higher than most other hospitalized patients. Nonadministration of pharmacologic VTE prophylaxis is common and is associated with VTE events. Our objective was to determine whether nonadministration of pharmacologic VTE prophylaxis is more common in patients with COVID-19 versus other hospitalized patients. Materials and methods: In this retrospective cohort analysis of all adult patients discharged from the Johns hopkins hospital between Mar 1 and May 12, 2020, we compared demographic, clinical characteristics, VTE outcomes, prescription and administration of VTE prophylaxis between COVID-19 positive, negative, and not tested groups. Results: Patients tested positive for COVID-19 were significantly older, and more likely to be Hispanic, have a higher median body mass index, have longer hospital length of stay, require mechanical ventilation, develop pulmonary embolism and die (all p < 0.001). COVID-19 patients were more likely to be prescribed (aOR 1.51, 95% CI 1.38–1.66) and receive all doses of prescribed pharmacologic VTE prophylaxis (aOR 1.48, 95% CI 1.36–1.62). The number of patients who missed at least one dose of VTE prophylaxis and developed VTE was similar between the three groups (p = 0.31). Conclusions: It is unlikely that high rates of VTE in COVID-19 are due to nonadministration of doses of pharmacologic prophylaxis. Hence, we should prioritize research into alternative approaches to optimizing VTE prevention in patients with COVID-19.

Original languageEnglish (US)
JournalJournal of Thrombosis and Thrombolysis
DOIs
StateAccepted/In press - 2021

Keywords

  • COVID-19
  • Deep vein thrombosis
  • Missed doses
  • Pulmonary embolism
  • Thromboprophylaxis
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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