Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To assess the prevalence of adherence to prescribed medications in children with Crohn disease and to identify possible factors associated with nonadherence. PATIENTS AND METHODS: This was a cross-sectional study of 51 pediatric patients with Crohn disease who were prescribed maintenance therapy with a thiopurine immunomodulator (6-mercaptopurine or azathioprine) and/or mesalamine during a 180-day period. Medication adherence rates were calculated from a validated formula using pharmacy records, and nonadherence was defined as a refill rate of <80% of the prescribed medication. Seventy-five percent of patients were prescribed thiopurine immunomodulators and 86% were prescribed mesalamine. RESULTS: The prevalence of nonadherence was 50% for the thiopurine immunomodulators and 66% for mesalamine. The mean number of emergency department visits for patients adherent to mesalamine was significantly greater than the nonadherent group (P < 0.0008). Having an emergency department visit increased the chances of a patient being adherent to mesalamine therapy by >9-fold (odds ratio, 9.6; 95% confidence interval, 1.87-52.17). The mean number of total health care visits was significantly greater for patients adherent to mesalamine (6.1 ± 0.8) compared with those who were not adherent (3.0 ± 0.4) (P < 0.001). CONCLUSIONS: These findings suggest that nonadherence to thiopurine immunomodulator or mesalamine therapy in pediatric patients with Crohn disease is common. Having a health care visit was associated with being adherent.

Original languageEnglish (US)
Pages (from-to)180-184
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume44
Issue number2
DOIs
StatePublished - Feb 1 2007

Keywords

  • 6-Mercaptopurine
  • Adherence
  • Azathioprine
  • Child
  • Compliance
  • Crohn disease
  • Inflammatory bowel disease
  • Medication
  • Mesalamine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Fingerprint Dive into the research topics of 'Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease'. Together they form a unique fingerprint.

  • Cite this