Abstract
Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous carcinoma, adenocarcinoma, small cell carcinoma, sarcomatoid carcinoma, and sinonasal carcinoma with adenoid cystic-like features.
Original language | English (US) |
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Pages (from-to) | 301-307 |
Number of pages | 7 |
Journal | Diagnostic Histopathology |
Volume | 20 |
Issue number | 8 |
DOIs | |
State | Published - 2014 |
Keywords
- Adenocarcinoma
- Adenosquamous carcinoma
- HPV
- Human papillomavirus
- Sarcomatoid carcinoma
- Sinonasal carcinoma with adenoid cystic-like features
- Small cell carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology