Non-sequential expression of multiple immunoglobulin classes by isolated B-cell clones

Patricia J. Gearhart

Research output: Contribution to journalArticlepeer-review

Abstract

As humoral immunity to a given antigen is generally thought to display an early IgM response which is later dominated by IgG synthesis, it has long been thought that clones of antibody-producing cells switched from μ to γ (refs 1-5). The sequence of appearance of immunoglobulin classes produced by the progeny of isolated precursors (B cells) to antibody-forming cells may answer the questions (1) does a clone of cells switch from μ to γ to α, and (2) do all clones switch in the same order following antigen stimulation? Results presented here show that there is no order of expression of immunoglobulin class with time by B-cell clones stimulated by antigen in the presence of carrier help, because any class can appear first or simultaneously with any other class.

Original languageEnglish (US)
Pages (from-to)812-813
Number of pages2
JournalNature
Volume269
Issue number5631
DOIs
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • General

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