Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates

J. B. De Vis, E. T. Petersen, T. Alderliesten, F. Groenendaal, L. S. de Vries, F. van Bel, M. J.N.L. Benders, J. Hendrikse

Research output: Contribution to journalArticle

Abstract

Background and purpose: Brain oxygen consumption reflects neuronal activity and can therefore be used to investigate brain development or neuronal injury in neonates. In this paper we present the first results of a non-invasive MRI method to evaluate whole brain oxygen consumption in neonates. Materials and methods: For this study 51 neonates were included. The T1 and T2 of blood in the sagittal sinus were fitted using the 'T2 prepared tissue relaxation inversion recovery' pulse sequence (T2-TRIR). From the T1 and the T2 of blood, the venous oxygenation and the oxygen extraction fraction (OEF) were calculated. The cerebral metabolic rate of oxygen (CMRO2) was the resultant of the venous oxygenation and arterial spin labeling whole brain cerebral blood flow (CBF) measurements. Results: Venous oxygenation was 59±14% (mean±sd), OEF was 40±14%, CBF was 14±5ml/100g/min and CMRO2 was 30±12μmol/100g/min. The OEF in preterms at term-equivalent age was higher than in the preterms and in the infants with hypoxic-ischemic encephalopathy (p<0.01). The OEF, CBF and CMRO2 increased (p<0.01, <0.05 and <0.01, respectively) with postnatal age. Conclusion: We presented an MRI technique to evaluate whole-brain oxygen consumption in neonates non-invasively. The measured values are in line with reference values found by invasive measurement techniques. Preterms and infants with HIE demonstrated significant lower oxygen extraction fraction than the preterms at term-equivalent age. This could be due to decreased neuronal activity as a reflection of brain development or as a result of tissue damage, increased cerebral blood flow due to immature or impaired autoregulation, or could be caused by differences in postnatal age.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalNeuroImage
Volume95
DOIs
StatePublished - Jul 15 2014
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Oxygen Consumption
Newborn Infant
Oxygen
Brain
Premature Infants
Brain Hypoxia-Ischemia
Reference Values
Homeostasis
Wounds and Injuries

Keywords

  • Arterial spin labeling
  • Cerebral blood flow
  • Cerebral metabolic rate of oxygen
  • Neonates
  • Oxygen consumption
  • Venous oxygenation

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

De Vis, J. B., Petersen, E. T., Alderliesten, T., Groenendaal, F., de Vries, L. S., van Bel, F., ... Hendrikse, J. (2014). Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates. NeuroImage, 95, 185-192. https://doi.org/10.1016/j.neuroimage.2014.03.060

Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates. / De Vis, J. B.; Petersen, E. T.; Alderliesten, T.; Groenendaal, F.; de Vries, L. S.; van Bel, F.; Benders, M. J.N.L.; Hendrikse, J.

In: NeuroImage, Vol. 95, 15.07.2014, p. 185-192.

Research output: Contribution to journalArticle

De Vis, JB, Petersen, ET, Alderliesten, T, Groenendaal, F, de Vries, LS, van Bel, F, Benders, MJNL & Hendrikse, J 2014, 'Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates', NeuroImage, vol. 95, pp. 185-192. https://doi.org/10.1016/j.neuroimage.2014.03.060
De Vis, J. B. ; Petersen, E. T. ; Alderliesten, T. ; Groenendaal, F. ; de Vries, L. S. ; van Bel, F. ; Benders, M. J.N.L. ; Hendrikse, J. / Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates. In: NeuroImage. 2014 ; Vol. 95. pp. 185-192.
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abstract = "Background and purpose: Brain oxygen consumption reflects neuronal activity and can therefore be used to investigate brain development or neuronal injury in neonates. In this paper we present the first results of a non-invasive MRI method to evaluate whole brain oxygen consumption in neonates. Materials and methods: For this study 51 neonates were included. The T1 and T2 of blood in the sagittal sinus were fitted using the 'T2 prepared tissue relaxation inversion recovery' pulse sequence (T2-TRIR). From the T1 and the T2 of blood, the venous oxygenation and the oxygen extraction fraction (OEF) were calculated. The cerebral metabolic rate of oxygen (CMRO2) was the resultant of the venous oxygenation and arterial spin labeling whole brain cerebral blood flow (CBF) measurements. Results: Venous oxygenation was 59±14{\%} (mean±sd), OEF was 40±14{\%}, CBF was 14±5ml/100g/min and CMRO2 was 30±12μmol/100g/min. The OEF in preterms at term-equivalent age was higher than in the preterms and in the infants with hypoxic-ischemic encephalopathy (p<0.01). The OEF, CBF and CMRO2 increased (p<0.01, <0.05 and <0.01, respectively) with postnatal age. Conclusion: We presented an MRI technique to evaluate whole-brain oxygen consumption in neonates non-invasively. The measured values are in line with reference values found by invasive measurement techniques. Preterms and infants with HIE demonstrated significant lower oxygen extraction fraction than the preterms at term-equivalent age. This could be due to decreased neuronal activity as a reflection of brain development or as a result of tissue damage, increased cerebral blood flow due to immature or impaired autoregulation, or could be caused by differences in postnatal age.",
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AU - de Vries, L. S.

AU - van Bel, F.

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