Non-invasive methods to detect schistosome-based bladder cancer: is the association sufficient for epidemiological use?

Clive Shiff, Jean M. Naples, Sumit Isharwal, Kwabena M. Bosompem, Robert W. Veltri

Research output: Contribution to journalReview article

Abstract

The association between chronic infection with Schistosoma haematobium and squamous cell carcinoma of the bladder is well known but there are few epidemiological data available to assess the extent of this cancer in schistosome-endemic areas. Invasive surgical procedures are not practical for epidemiological appraisal, therefore this important health matter is unresolved. This review examines recent work done to identify and detect biomarkers that can be found in voided urine and therefore obtained without invasive procedures. A variety of products of cell cycle kinetics, nuclear activity enzymes and even nuclear morphometry have been studied in urine specimens and these in concert may be sufficient to indicate the likelihood of the presence of bladder cancer or some predictive pre-cancerous state. Although these techniques require a sophisticated central laboratory for analysis, specimens can easily be collected in the field and brought to the centre, which could serve regional programmes. We suggest that early diagnosis of pre-cancerous conditions associated with urinary schistosomiasis, if appropriately treated, could save countless lives.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume104
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Biomarkers
  • Bladder cancer
  • Diagnosis
  • Schistosoma haematobium
  • Squamous cell carcinoma
  • Urinary schistosomiasis

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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