Non-invasive indicators of pulmonary hypertension from pulmonary veins quantification in sickle cell disease

Guido H. Jajamovich, Vivek Pamulapati, Shoaib Alam, Alem Mehari, Gregory J. Kato, Bradford J. Wood, Marius George Linguraru

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pulmonary hypertension is a common cause of death among patients with sickle cell disease. This retrospective study investigates the use of pulmonary vein analysis to diagnose pulmonary hypertension non-invasively with CT-Angiography images. Ten images from patients with pulmonary hypertension were matched with controls. An adaptive fast marching approach is applied in order to segment the left atrium and pulmonary veins, followed by a geodesic active contour to isolate the atrium. The ostia of the pulmonary veins are determined by computing the skeleton and finding the intersections with the contour of the atrium. 96.3% of the ostia are identified correctly by the technique. The diameters of the veins are then measured and their sum is computed at fixed distances from the ostium. These quantitative indicators are significantly larger in patients as compared to controls (p-values < 0.01). Furthermore, the non-invasive estimations of the method present a high and significant correlation with the clinical hemodynamics measurements obtained from right heart catheterization.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages840-843
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

    Fingerprint

Keywords

  • Pulmonary hypertension
  • pulmonary veins
  • quantification
  • segmentation
  • sickle cell disease

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Jajamovich, G. H., Pamulapati, V., Alam, S., Mehari, A., Kato, G. J., Wood, B. J., & Linguraru, M. G. (2012). Non-invasive indicators of pulmonary hypertension from pulmonary veins quantification in sickle cell disease. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 840-843). [6235679] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2012.6235679