Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography

M. Seeck, F. Lazeyras, C. M. Michel, O. Blanke, C. A. Gericke, J. Ives, J. Delavelle, X. Golay, C. A. Haenggeli, N. De Tribolet, T. Landis

Research output: Contribution to journalArticlepeer-review

Abstract

We present a new approach for non-invasive localization of focal epileptogenic discharges in patients considered for surgical treatment. EEG- triggered functional MR imaging (fMRI) and 3D EEG source localization were combined to map the primary electrical source with high spatial resolution. The method is illustrated by the case of a patient with medically intractable frontal lobe epilepsy. EEG obtained in the MRI system allowed triggering of the fMRI acquisition by the patient's habitual epileptogenic discharges. fMRI revealed multiple areas of signal enhancement. Three-dimensional EEG source localization identified the same active areas and provided evidence of onset in the left frontal lobe. Subsequent electrocorticography from subdural electrodes confirmed spike and seizure onset over this region. This approach, i.e. the combination of EEG-triggered fMRI and 3D EEG source analysis, represents a promising additional tool for presurgical epilepsy evaluation allowing precise non-invasive identification of the epileptic foci.

Original languageEnglish (US)
Pages (from-to)508-512
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology
Volume106
Issue number6
DOIs
StatePublished - Jun 1998

Keywords

  • EEG
  • Electromagnetic tomography
  • Epilepsy
  • Functional MRI
  • Localization
  • Surgery

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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