@article{aa7181eec78c41ff97ac2de78a9e9752,
title = "Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype",
abstract = "Interleukin-10 (IL10) may contribute to the development of non-Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003). In longitudinal studies, detectable IL10 occurred at times closest to but preceding lymphoma diagnosis (P = 0.01). In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (-592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma.",
keywords = "AIDS, B cell, Cytokine, Genotype, Haplotype, Interleukin-10, Lymphoma, Predictor, Serum, Single-nucleotide polymorphism",
author = "Breen, {Elizabeth Crabb} and Boscardin, {W. John} and Roger Detels and Jacobson, {Lisa P.} and Smith, {Michael W.} and O'Brien, {Stephen J.} and Chmiel, {Joan S.} and Rinaldo, {Charles R.} and Shenghan Lai and Otoniel Mart{\'i}nez-Maza",
note = "Funding Information: Data in this manuscript were collected by the Multicenter AIDS Cohort Study with centers (Principal Investigators) at The Johns Hopkins School of Public Health (Joseph B. Margolick, Alvaro Mu{\~n}oz), Howard Brown Health Center and Northwestern University Medical School (John Phair), University of California, Los Angeles (Roger Detels, Beth Jamieson), and University of Pittsburgh (Charles Rinaldo). This work was supported by grants from the National Institutes of Health (CA57152, CD73475, AI35040, CA96888), and the University wide AIDS Research Program through a grant to the UCLA California AIDS Research Center (CC99-LA-002). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute (U01-AI35042, 5-M01-RR00722 (GCRC), U01-A135043, U01-AI37984, U01-A135039, U01-AI35040, U01-AI37613, U01-AI35041). This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. N01-CO56000.",
year = "2003",
month = nov,
doi = "10.1016/S1521-6616(03)00214-6",
language = "English (US)",
volume = "109",
pages = "119--129",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",
}