Non-Hodgkin Lymphoma Metabolism

Brian James Kirsch, Shu Jyuan Chang, Michael James Betenbaugh, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter


Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of lymphoid neoplasms with different biological characteristics. About 90% of all lymphomas in the United States originate from B lymphocytes, while the remaining originate from T cells [1]. The treatment of NHLs depends on the neoplastic histology and stage of the tumor, which will indicate whether radiotherapy, chemotherapy, or a combination is the best suitable treatment [2]. The American Cancer Society describes the staging of lymphoma as follows: Stage I is lymphoma in a single node or area. Stage II is when that lymphoma has spread to another node or organ tissue. Stage III is when it has spread to lymph nodes on two sides of the diaphragm. Stage IV is when cancer has significantly spread to organs outside the lymph system. Radiation therapy is the traditional therapeutic route for localized follicular and mucosa-associated lymphomas. Chemotherapy is utilized for the treatment of large-cell lymphomas and high-grade lymphomas [2]. However, the treatment of indolent lymphomas remains problematic as the patients often have metastasis, for which no standard approach exists [2].

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages14
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Aerobic glycolysis
  • Fatty acid metabolism
  • Gene expression
  • Glutamine metabolism
  • Heterogeneous malignant lymphomas
  • Lactic acidosis
  • PI3K/AKT/mTOR pathway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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