@inbook{da236c4071dd4e75a91ee0f39c84a0dc,
title = "Non-hodgkin lymphoma metabolism",
abstract = "Aggressive lymphomas exhibit the Warburg effect.Lactic acidosis is a result of overproduction of lactate and leads to a fatal prognosis.Mutation of p53 helps cancer cells survive glutamine deprivation.PI3K regulates fatty acid synthesis (FAS) in primary effusion lymphoma (PEL) and other B-NHLs.AMPK regulates NADPH balance for fatty acid oxidation as a means of supplementing the TCA cycle.PRPS2 couples protein and nucleotide biosynthesis to drive lymphomagenesis.mTOR activation promotes fatty acid synthesis (FAS).MYC regulates cancer cell metabolism under glucose-deprived and hypoxic conditions.HIF-1 acts as a regulator in hypoxia adaption and the related metabolic change.",
keywords = "Aerobic glycolysis, Fatty acid metabolism, Gene expression, Glutamine metabolism, Heterogeneous malignant lymphomas, Lactic acidosis, mTOR signaling",
author = "Kirsch, {Brian James} and Chang, {Shu Jyuan} and Anne Le",
note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
doi = "10.1007/978-3-319-77736-8_7",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "95--106",
booktitle = "Advances in Experimental Medicine and Biology",
}