Non-hodgkin lymphoma metabolism

Brian James Kirsch, Shu Jyuan Chang, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aggressive lymphomas exhibit the Warburg effect.Lactic acidosis is a result of overproduction of lactate and leads to a fatal prognosis.Mutation of p53 helps cancer cells survive glutamine deprivation.PI3K regulates fatty acid synthesis (FAS) in primary effusion lymphoma (PEL) and other B-NHLs.AMPK regulates NADPH balance for fatty acid oxidation as a means of supplementing the TCA cycle.PRPS2 couples protein and nucleotide biosynthesis to drive lymphomagenesis.mTOR activation promotes fatty acid synthesis (FAS).MYC regulates cancer cell metabolism under glucose-deprived and hypoxic conditions.HIF-1 acts as a regulator in hypoxia adaption and the related metabolic change.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages95-106
Number of pages12
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Aerobic glycolysis
  • Fatty acid metabolism
  • Gene expression
  • Glutamine metabolism
  • Heterogeneous malignant lymphomas
  • Lactic acidosis
  • mTOR signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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