Non-high-density lipoprotein cholesterol, guideline targets, and population percentiles for secondary prevention in 1.3 million adults

The VLDL-2 study (very large database of lipids)

Mohamed B. Elshazly, Seth Martin, Michael Blaha, Parag H. Joshi, Peter P. Toth, John W. McEvoy, Mohammed A. Al-Hijji, Krishnaji R. Kulkarni, Peter O. Kwiterovich, Roger S Blumenthal, Steven Jones

Research output: Contribution to journalArticle

Abstract

Objectives This study sought to examine patient-level discordance between population percentiles of non-high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Background Non-HDL-C is an alternative to LDL-C for risk stratification and lipid-lowering therapy. The justification for the present guideline-based non-HDL-C cutpoints of 30 mg/dl higher than the LDL-C cutpoints remains largely untested. Methods We assigned population percentiles to non-HDL-C and Friedewald-estimated LDL-C values of 1,310,440 U.S. adults with triglyceride levels

Original languageEnglish (US)
Pages (from-to)1960-1965
Number of pages6
JournalJournal of the American College of Cardiology
Volume62
Issue number21
DOIs
StatePublished - Nov 19 2013

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Health Services Needs and Demand
Secondary Prevention
LDL Cholesterol
Databases
Guidelines
Lipids
HDL Cholesterol
Population
Triglycerides
lipoprotein cholesterol
Therapeutics

Keywords

  • discordance
  • LDL cholesterol
  • lipids
  • non-HDL cholesterol
  • percentiles
  • secondary prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Non-high-density lipoprotein cholesterol, guideline targets, and population percentiles for secondary prevention in 1.3 million adults : The VLDL-2 study (very large database of lipids). / Elshazly, Mohamed B.; Martin, Seth; Blaha, Michael; Joshi, Parag H.; Toth, Peter P.; McEvoy, John W.; Al-Hijji, Mohammed A.; Kulkarni, Krishnaji R.; Kwiterovich, Peter O.; Blumenthal, Roger S; Jones, Steven.

In: Journal of the American College of Cardiology, Vol. 62, No. 21, 19.11.2013, p. 1960-1965.

Research output: Contribution to journalArticle

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