Non-contrast MR imaging of blood-brain barrier permeability to water

Zixuan Lin, Yang Li, Pan Su, Deng Mao, Zhiliang Wei, Jay Pillai, Abhay R Moghekar, Matthias van Osch, Yulin Ge, Hanzhang Lu

Research output: Contribution to journalArticle

Abstract

Purpose: Many brain diseases are associated with an alteration in blood-brain barrier (BBB) and its permeability. Current methods using contrast agent are primarily sensitive to major leakage of BBB to macromolecules, but may not detect subtle changes in BBB permeability. The present study aims to develop a novel non-contrast MRI technique for the assessment of BBB permeability to water. Methods: The central principle is that by measuring arterially labeled blood spins that are drained into cerebral veins, water extraction fraction (E) and permeability-surface-area product (PS) of BBB can be determined. Four studies were performed. We first demonstrated the proof-of-principle using conventional ASL with very long post-labeling delays (PLD). Next, a new sequence, dubbed water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST), and its Look-Locker (LL) version were developed. Finally, we demonstrated that the sensitivity of the technique can be significantly enhanced by acquiring the data under mild hypercapnia. Results: By combining a strong background suppression with long PLDs (2500-4500 ms), ASL spins were reliably detected in the superior sagittal sinus (SSS), demonstrating the feasibility of measuring this signal. The WEPCAST sequence eliminated partial voluming effects of tissue perfusion and allowed quantitative estimation of E=95.5±1.1% and PS=188.9±13.4mL/100g/min, which were in good agreement with literature reports. LL-WEPCAST sequence shortened the scan time from 19min to 5min while providing results consistent with multiple single-PLD acquisitions. Mild hypercapnia increased SNR by 78±25% without causing a discomfort in participants. Conclusion: A new non-contrast technique for the assessment of global BBB permeability was developed, which may have important clinical applications.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Blood-Brain Barrier
Permeability
Water
Hypercapnia
Superior Sagittal Sinus
Cerebral Veins
Brain Diseases
Contrast Media
Perfusion

Keywords

  • Arterial-spin-labeling
  • Blood-brain barrier
  • Permeability
  • Phase-contrast
  • Superior sagittal sinus
  • Water extraction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Non-contrast MR imaging of blood-brain barrier permeability to water. / Lin, Zixuan; Li, Yang; Su, Pan; Mao, Deng; Wei, Zhiliang; Pillai, Jay; Moghekar, Abhay R; van Osch, Matthias; Ge, Yulin; Lu, Hanzhang.

In: Magnetic Resonance in Medicine, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Purpose: Many brain diseases are associated with an alteration in blood-brain barrier (BBB) and its permeability. Current methods using contrast agent are primarily sensitive to major leakage of BBB to macromolecules, but may not detect subtle changes in BBB permeability. The present study aims to develop a novel non-contrast MRI technique for the assessment of BBB permeability to water. Methods: The central principle is that by measuring arterially labeled blood spins that are drained into cerebral veins, water extraction fraction (E) and permeability-surface-area product (PS) of BBB can be determined. Four studies were performed. We first demonstrated the proof-of-principle using conventional ASL with very long post-labeling delays (PLD). Next, a new sequence, dubbed water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST), and its Look-Locker (LL) version were developed. Finally, we demonstrated that the sensitivity of the technique can be significantly enhanced by acquiring the data under mild hypercapnia. Results: By combining a strong background suppression with long PLDs (2500-4500 ms), ASL spins were reliably detected in the superior sagittal sinus (SSS), demonstrating the feasibility of measuring this signal. The WEPCAST sequence eliminated partial voluming effects of tissue perfusion and allowed quantitative estimation of E=95.5±1.1{\%} and PS=188.9±13.4mL/100g/min, which were in good agreement with literature reports. LL-WEPCAST sequence shortened the scan time from 19min to 5min while providing results consistent with multiple single-PLD acquisitions. Mild hypercapnia increased SNR by 78±25{\%} without causing a discomfort in participants. Conclusion: A new non-contrast technique for the assessment of global BBB permeability was developed, which may have important clinical applications.",
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AU - Li, Yang

AU - Su, Pan

AU - Mao, Deng

AU - Wei, Zhiliang

AU - Pillai, Jay

AU - Moghekar, Abhay R

AU - van Osch, Matthias

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