Non-contact holmium: YAG laser thermal keratoplasty for treatment of hyperopia. 18-month follow-up of the U.S. phase IIa clinical trial

D. D. Koch, T. Kohnen, Peter J McDonnell, R. F. Menefee, M. J. Berry

Research output: Contribution to journalArticle

Abstract

Purpose. To assess the safety and efficacy of holmium:YAG laser thermal keratoplasty (Ho:YAG LTK) for the correction of hyperopia. Methods. We report the 18-month follow-up on sighted eyes treated in the Sunrise U.S. Phase IIa clinical study. 18/8 eyes of 18/8 patients were treated with 1/2 rings of 8 laser spots per ring on 6/6 + 7 mm ring diameters using ten laser pulses per ring with variable pulse energies in the range 208 to 242 mJ. Results. At 18 months post-treatment, mean changes in subjective manifest refraction were -0.49/-1.54 D for 13/6 eyes in the 1/2 ring groups. Regressions were 0.05/0.10 D from the 12-month follow-up changes. Mean uncorrected distance visual acuities improved from 0.30/0.15 (ca. 20/70 and 20/125) to 0.49/0.34 (ca. 20/40 and 20/60). No eyes lost more than one line of best spectacle-corrected visual acuity. The mean endothelial cell densities were unchanged. Conclusions. Ho:YAG LTK is a safe and effective treatment for low hyperopia. Two rings of treatment spots produce considerably more refractive correction than one ring.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

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Hyperopia
Corneal Transplantation
Solid-State Lasers
Hot Temperature
Clinical Trials
Visual Acuity
Lasers
Therapeutics
Endothelial Cells
Cell Count
Safety

ASJC Scopus subject areas

  • Ophthalmology

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Non-contact holmium : YAG laser thermal keratoplasty for treatment of hyperopia. 18-month follow-up of the U.S. phase IIa clinical trial. / Koch, D. D.; Kohnen, T.; McDonnell, Peter J; Menefee, R. F.; Berry, M. J.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

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