Non-canonical Notch signaling: Emerging role and mechanism

Peter Andersen, Hideki Uosaki, Lincoln T. Shenje, Chulan Kwon

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations


Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalTrends in Cell Biology
Issue number5
StatePublished - May 2012


  • Cancer
  • DAPT
  • Notch
  • Numb
  • Stem and progenitor cells
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Cell Biology


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