Non-alcoholic steatohepatitis-related hepatocellular carcinoma: A growing epidemic?

Adam C. Yopp, Michael A. Choti

Research output: Contribution to journalArticle

Abstract

Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC.

Original languageEnglish (US)
Pages (from-to)642-647
Number of pages6
JournalDigestive Diseases
Volume33
Issue number5
DOIs
StatePublished - Dec 1 2015

Keywords

  • Cryptogenic cirrhosis
  • Hepatocellular carcinoma
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • Phospholipase domain-containing 3

ASJC Scopus subject areas

  • Gastroenterology

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