Non-alcoholic steatohepatitis-related hepatocellular carcinoma: A growing epidemic?

Adam C. Yopp; Michael A. Choti

doi:10.1159/000438473

Non-alcoholic steatohepatitis-related hepatocellular carcinoma: A growing epidemic?

Adam C. Yopp, Michael A. Choti

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC.

Original language	English (US)
Pages (from-to)	642-647
Number of pages	6
Journal	Digestive Diseases
Volume	33
Issue number	5
DOIs	https://doi.org/10.1159/000438473
State	Published - Dec 1 2015

Keywords

Cryptogenic cirrhosis
Hepatocellular carcinoma
Metabolic syndrome
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Phospholipase domain-containing 3

ASJC Scopus subject areas

Gastroenterology

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10.1159/000438473

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title = "Non-alcoholic steatohepatitis-related hepatocellular carcinoma: A growing epidemic?",

abstract = "Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC.",

keywords = "Cryptogenic cirrhosis, Hepatocellular carcinoma, Metabolic syndrome, Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Phospholipase domain-containing 3",

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AU - Choti, Michael A.

PY - 2015/12/1

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N2 - Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC.

AB - Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC.

KW - Cryptogenic cirrhosis

KW - Hepatocellular carcinoma

KW - Metabolic syndrome

KW - Non-alcoholic fatty liver disease

KW - Non-alcoholic steatohepatitis

KW - Phospholipase domain-containing 3

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Non-alcoholic steatohepatitis-related hepatocellular carcinoma: A growing epidemic?

Abstract

Keywords

ASJC Scopus subject areas

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