TY - JOUR
T1 - Non-alcoholic fatty liver disease
T2 - Lumen-liver interactions and possible role for probiotics
AU - Solga, Steven F.
AU - Diehl, A. M.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - NAFLD is a common and serious disease. The pathogenesis of NAFLD continues to be elaborated. Recent progress suggests some commonality with the pathogenesis of AFLD; specifically, the importance of lumen-liver interactions and increased activity of TNF-α. Such understanding furthers interest in the intestinal flora, which may be an appropriate target for therapy. Such therapy should be safe, well-tolerated, inexpensive, appropriate for long term use, and optimally, work at multiple levels to down-regulate inflammatory mediators. Probiotics could be an option.
AB - NAFLD is a common and serious disease. The pathogenesis of NAFLD continues to be elaborated. Recent progress suggests some commonality with the pathogenesis of AFLD; specifically, the importance of lumen-liver interactions and increased activity of TNF-α. Such understanding furthers interest in the intestinal flora, which may be an appropriate target for therapy. Such therapy should be safe, well-tolerated, inexpensive, appropriate for long term use, and optimally, work at multiple levels to down-regulate inflammatory mediators. Probiotics could be an option.
UR - http://www.scopus.com/inward/record.url?scp=0037879075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037879075&partnerID=8YFLogxK
U2 - 10.1016/S0168-8278(03)00097-7
DO - 10.1016/S0168-8278(03)00097-7
M3 - Article
C2 - 12713883
AN - SCOPUS:0037879075
SN - 0168-8278
VL - 38
SP - 681
EP - 687
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 5
ER -