NAFLD is a common and serious disease. The pathogenesis of NAFLD continues to be elaborated. Recent progress suggests some commonality with the pathogenesis of AFLD; specifically, the importance of lumen-liver interactions and increased activity of TNF-α. Such understanding furthers interest in the intestinal flora, which may be an appropriate target for therapy. Such therapy should be safe, well-tolerated, inexpensive, appropriate for long term use, and optimally, work at multiple levels to down-regulate inflammatory mediators. Probiotics could be an option.
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