Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics

Steven F. Solga, A. M. Diehl

Research output: Contribution to journalArticle

Abstract

NAFLD is a common and serious disease. The pathogenesis of NAFLD continues to be elaborated. Recent progress suggests some commonality with the pathogenesis of AFLD; specifically, the importance of lumen-liver interactions and increased activity of TNF-α. Such understanding furthers interest in the intestinal flora, which may be an appropriate target for therapy. Such therapy should be safe, well-tolerated, inexpensive, appropriate for long term use, and optimally, work at multiple levels to down-regulate inflammatory mediators. Probiotics could be an option.

Original languageEnglish (US)
Pages (from-to)681-687
Number of pages7
JournalJournal of Hepatology
Volume38
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Gastroenterology

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