Nodular lymphocyte-predominant Hodgkin lymphoma cytopathologic correlates on fine-needle aspiration

Andrea P. Subhawong, Syed Z Ali, Armanda D. Tatsas

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literature because it was only formally recognized as a distinct entity in 1994. METHODS: In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine-needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features. RESULTS: Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei. CONCLUSIONS: Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalCancer cytopathology
Volume120
Issue number4
DOIs
StatePublished - Aug 25 2012

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Fine Needle Biopsy
Hodgkin Disease
Histiocytes
Lymphoid Tissue
Diagnostic Errors
Cell Biology
Neoplasms
Lymph Nodes
Lymphocytes
Biopsy
Recurrence

Keywords

  • Cytopathology
  • Fine-needle aspiration
  • Lymphocyte-predominant cell
  • Nodular lymphocyte-predominant Hodgkin lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Nodular lymphocyte-predominant Hodgkin lymphoma cytopathologic correlates on fine-needle aspiration. / Subhawong, Andrea P.; Ali, Syed Z; Tatsas, Armanda D.

In: Cancer cytopathology, Vol. 120, No. 4, 25.08.2012, p. 254-260.

Research output: Contribution to journalArticle

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