Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma

P. J. Santrach, Frederic B Askin, R. J. Wells, R. G. Azizkhan, D. F. Merten

Research output: Contribution to journalArticle

Abstract

Bleomycin (BLEO), an antitumor antibiotic effective against a variety of malignancies, has been associated classically with a pulmonary toxic reaction producing diffuse interstitial fibrosis. However, BLEO-related pulmonary nodules have been reported recently, mostly in children and young adults treated for germ cell tumors. A different, apparent hypersensitivity reaction with prominent eosinophilic infiltrates has been seen in other patients. This report details the clinical history, radiographic features, and histopathologic condition of three patients with osteogenic sarcoma in whom pulmonary nodules developed during the course of their multiagent, BLEO-containing chemotherapy. The predominant histopathologic lesion was bronchiolitis obliterans-organizing pneumonia (BOOP); one patient had a significant eosinophilic infiltrate also. Pulmonary lesions developed in all of these patients after relatively low doses of BLEO (<200 mg). All of these patients underwent open lung biopsy to establish the diagnosis. Reported cases of BLEO-induced pulmonary injury other than diffuse fibrosis are reviewed and comparisons are made with those in the current report. Also, suggestions are made for the management of these patients.

Original languageEnglish (US)
Pages (from-to)806-811
Number of pages6
JournalCancer
Volume64
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Bleomycin
Lung Injury
Osteosarcoma
Lung
Fibrosis
Cryptogenic Organizing Pneumonia
Germ Cell and Embryonal Neoplasms
Poisons
Young Adult
Hypersensitivity
Anti-Bacterial Agents
Biopsy
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Santrach, P. J., Askin, F. B., Wells, R. J., Azizkhan, R. G., & Merten, D. F. (1989). Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. Cancer, 64(4), 806-811.

Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. / Santrach, P. J.; Askin, Frederic B; Wells, R. J.; Azizkhan, R. G.; Merten, D. F.

In: Cancer, Vol. 64, No. 4, 1989, p. 806-811.

Research output: Contribution to journalArticle

Santrach, PJ, Askin, FB, Wells, RJ, Azizkhan, RG & Merten, DF 1989, 'Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma', Cancer, vol. 64, no. 4, pp. 806-811.
Santrach PJ, Askin FB, Wells RJ, Azizkhan RG, Merten DF. Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. Cancer. 1989;64(4):806-811.
Santrach, P. J. ; Askin, Frederic B ; Wells, R. J. ; Azizkhan, R. G. ; Merten, D. F. / Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. In: Cancer. 1989 ; Vol. 64, No. 4. pp. 806-811.
@article{1d6c1a0c16094ff5ad7aef02563f8b18,
title = "Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma",
abstract = "Bleomycin (BLEO), an antitumor antibiotic effective against a variety of malignancies, has been associated classically with a pulmonary toxic reaction producing diffuse interstitial fibrosis. However, BLEO-related pulmonary nodules have been reported recently, mostly in children and young adults treated for germ cell tumors. A different, apparent hypersensitivity reaction with prominent eosinophilic infiltrates has been seen in other patients. This report details the clinical history, radiographic features, and histopathologic condition of three patients with osteogenic sarcoma in whom pulmonary nodules developed during the course of their multiagent, BLEO-containing chemotherapy. The predominant histopathologic lesion was bronchiolitis obliterans-organizing pneumonia (BOOP); one patient had a significant eosinophilic infiltrate also. Pulmonary lesions developed in all of these patients after relatively low doses of BLEO (<200 mg). All of these patients underwent open lung biopsy to establish the diagnosis. Reported cases of BLEO-induced pulmonary injury other than diffuse fibrosis are reviewed and comparisons are made with those in the current report. Also, suggestions are made for the management of these patients.",
author = "Santrach, {P. J.} and Askin, {Frederic B} and Wells, {R. J.} and Azizkhan, {R. G.} and Merten, {D. F.}",
year = "1989",
language = "English (US)",
volume = "64",
pages = "806--811",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma

AU - Santrach, P. J.

AU - Askin, Frederic B

AU - Wells, R. J.

AU - Azizkhan, R. G.

AU - Merten, D. F.

PY - 1989

Y1 - 1989

N2 - Bleomycin (BLEO), an antitumor antibiotic effective against a variety of malignancies, has been associated classically with a pulmonary toxic reaction producing diffuse interstitial fibrosis. However, BLEO-related pulmonary nodules have been reported recently, mostly in children and young adults treated for germ cell tumors. A different, apparent hypersensitivity reaction with prominent eosinophilic infiltrates has been seen in other patients. This report details the clinical history, radiographic features, and histopathologic condition of three patients with osteogenic sarcoma in whom pulmonary nodules developed during the course of their multiagent, BLEO-containing chemotherapy. The predominant histopathologic lesion was bronchiolitis obliterans-organizing pneumonia (BOOP); one patient had a significant eosinophilic infiltrate also. Pulmonary lesions developed in all of these patients after relatively low doses of BLEO (<200 mg). All of these patients underwent open lung biopsy to establish the diagnosis. Reported cases of BLEO-induced pulmonary injury other than diffuse fibrosis are reviewed and comparisons are made with those in the current report. Also, suggestions are made for the management of these patients.

AB - Bleomycin (BLEO), an antitumor antibiotic effective against a variety of malignancies, has been associated classically with a pulmonary toxic reaction producing diffuse interstitial fibrosis. However, BLEO-related pulmonary nodules have been reported recently, mostly in children and young adults treated for germ cell tumors. A different, apparent hypersensitivity reaction with prominent eosinophilic infiltrates has been seen in other patients. This report details the clinical history, radiographic features, and histopathologic condition of three patients with osteogenic sarcoma in whom pulmonary nodules developed during the course of their multiagent, BLEO-containing chemotherapy. The predominant histopathologic lesion was bronchiolitis obliterans-organizing pneumonia (BOOP); one patient had a significant eosinophilic infiltrate also. Pulmonary lesions developed in all of these patients after relatively low doses of BLEO (<200 mg). All of these patients underwent open lung biopsy to establish the diagnosis. Reported cases of BLEO-induced pulmonary injury other than diffuse fibrosis are reviewed and comparisons are made with those in the current report. Also, suggestions are made for the management of these patients.

UR - http://www.scopus.com/inward/record.url?scp=0024390457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024390457&partnerID=8YFLogxK

M3 - Article

C2 - 2472865

AN - SCOPUS:0024390457

VL - 64

SP - 806

EP - 811

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -