no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene

S. Schulte-Merker, F. J.M. Van Eeden, M. E. Halpern, C. B. Kimmel, C. Nüsslein-Volhard

Research output: Contribution to journalArticle

Abstract

The mouse T (Brachyury) gene is required for normal mesoderm development and the extension of the body axis. Recently, two mutant alleles of a zebrafish gene, no tail (ntl), have been isolated. ntl mutant embryos resemble mouse T/T mutant embryos in that they lack a differentiated notochord and the caudal region of their bodies. We report here that this phenotype is caused by mutation of the zebrafish homologue of the T gene. While ntl embryos express mutant mRNA, they show no nuclear protein product. Later, expression of mRNA in mutants, but not in wild types, is greatly reduced along the dorsal midline where the notochord normally forms. This suggests that the protein is required for maintaining transcription of its own gene.

Original languageEnglish (US)
Pages (from-to)1009-1015
Number of pages7
JournalDevelopment
Volume120
Issue number4
StatePublished - Apr 1 1994
Externally publishedYes

Keywords

  • Brachyury
  • Notochord
  • Zebrafish
  • no tail

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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  • Cite this

    Schulte-Merker, S., Van Eeden, F. J. M., Halpern, M. E., Kimmel, C. B., & Nüsslein-Volhard, C. (1994). no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development, 120(4), 1009-1015.